Focuses on the various manifestations of diabetic neuropathies which considerably impair quality of life and prognosis of patients with diabetes.
Therefore, an early as possible detection of the manifold nerve alterations associated with diabetes and prediabetes as well as their risk factors which ultimately translates into specific intervention or prevention strategies are important research goals of the group. The topics of clinical research mainly include the distal symmetric polyneuropathy, neuropathic pain, cardiovascular autonomic neuropathy, diabetic gastropresis, and sexual dysfunction.
The group has developed, validated, and established numerous quantitative methods for early detection and characterization of nerve dysfunction and morphology in people with diabetes and prediabetes. Within the scope of projects on the epidemiology and pathophysiology of peripheral and autonomic neuropathies the group collaborates with several national and international institutions. In clinical intervention studies, novel approaches of pharmacological and non-pharmacological therapy of diabetic polyneuropathy and neuropathic pain are being explored. Lastly, the active participation in the development of national and international guidelines for the diagnosis and treatment of diabetic neuropathies (e.g. German Diabetes Association, American Diabetes Association) should contribute to improving the quality of patient care standards.
Aims
- To estimate the prevalence and risk factors of neuropathy in type 2 diabetes and prediabetes (IGT, IFG)
- To validate and establish screening methods for early detection of peripheral and autonomic nerve alterations
- To define the predictors and determinants of nerve dysfunction and pathology in recent-onset type 1 and type 2 diabetes
- To decipher the mechanisms and factors contributing to painful neuropathy as opposed to painless neuropathy
Team
Selected Publications
- Ziegler D, Bönhof GJ, Strom A, Straßburger K, Karusheva Y, Szendroedi J, Roden M for the GDS Group 2021. Progression and regression of nerve fibre pathology and dysfunction early in diabetes over 5 years. Brain. 144: 3251-3263. https://doi.org/10.1093/brain/awab330
- Strom A, Strassburger K, Schmuck M, Shevalye H, Davidson E, Zivehe F, Bönhof G, Reimer R, Belgardt B-F, Fleming T, Biermann B, Burkart V, Müssig K, Szendroedi J, Yorek MA, Fritsche E, Nawroth PP, Roden M, Ziegler D for the GDS Group 2021. Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models. Mol Metab. 43. https://doi.org/10.1016/j.molmet.2020.101114
- Kück J-L, Bönhof GJ, Strom A, Zaharia O-P, Müssig K, Szendroedi J, Roden M, Ziegler D for the GDS Group 2020. Impairment in Baroreflex Sensitivity in Recent-Onset Type 2 Diabetes Without Progression Over 5 Years. Diabetes. 69: 1011-1019. https://doi.org/10.2337/db19-0990
- Bönhof GJ, Herder C, Strom A, Papanas N, Roden M, Ziegler D 2019. Emerging biomarkers, tools, and treatments for diabetic polyneuropathy. Endocr Rev. 40: 153-192. https://doi.org/10.1210/er.2018-00107
- Püttgen S, Bönhof GJ, Strom A, Müssig K, Szendroedi J, Roden M, Ziegler D 2019. Augmented Corneal Nerve Fiber Branching in Painful Compared With Painless Diabetic Neuropathy. J Clin Endocrinol Metab. 104: 6220-6228. https://doi.org/10.1210/jc.2019-01072
- Ziegler D, Strom A, Bönhof GJ., Kannenberg JM, Heier M, Rathmann W, Peter A, Meisinger C, Roden M, Thorand B, Herder C 2019. Deficits in systemic biomarkers of neuroinflammation and growth factors promoting nerve regeneration in patients with type 2 diabetes and polyneuropathy. BMJ Open Diabetes Res Care. 7. https://doi.org/10.1136/bmjdrc-2019-000752
- Ziegler D, Strom A, Kupriyanova Y, Bierwagen A, Bönhof GJ, Bódis K, Müssig K, Szendroedi J, Bobrov P, Markgraf DF, Hwang J-H, Roden M for the GDS Group 2018. Association of lower cardiovagal tone and baroreflex sensitivity with higher liver fat content early in type 2 diabetes. J Clin Endocrinol Metab. 103: 1130-1138. https://doi.org/10.1210/jc.2017-02294
- Ziegler D, Strom A, Bönhof G, Püttgen S, Bódis K, Burkart V, Müssig K, Szendrödi J, Markgraf D, Roden M for the GDS Group 2018. Differential associations of lower cardiac vagal tone with insulin resistance and insulin secretion in recently diagnosed type 1 and type 2 diabetes. Metab-Clin Exp. 79: 1-9. https://doi.org/10.1016/j.metabol.2017.10.013
- Röhling M, Strom A, Bönhof G, Püttgen S, Bódis K, Müssig K, Szendrödi J, Markgraf D, Lehr S, Roden M, Ziegler D for the GDS Group 2017. Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes. Diabetes Care. 40: 246-252. https://doi.org/10.2337/dc16-1898
- Boenhof G, Strom A, Puettgen S, Ringel B, Brueggemann J, Bódis K, Müssig K, Szendrödi J, Roden M, Ziegler D 2017. Patterns of cutaneous nerve fibre loss and regeneration in type 2 diabetes with painful and painless polyneuropathy. Diabetologia. 60: 2495-2503. https://doi.org/10.1007/s00125-017-4438-5
- Universität Heidelberg: J. Szendrödi, T. Fleming
- IUF, Düsseldorf: E. Fritsche
- Universität Düsseldorf: B. Biermann
- Ernst-Abbe-Fachhochschule Jena: A. Voss
- Helmholtz Zentrum München: C. Meisinger, A. Peters
- University of Iowa, Iowa City, USA: M. Yorek
Teaching Activities at Heinrich-Heine University Düsseldorf
- Wahlfach „Einführung ins wissenschaftliche Arbeiten“ (Strom)
- Wahlfach „Diabetes und Begleiterkrankungen“ (Strom, Bönhof)
- Wahlfach „Endokrinologie“ (Bönhof)
- Praxisblock „Diabetologie und Endokrinologie“ (Bönhof)