Im Labor bei der AG Pathiobiochemie

Molecular basis for the development of obesity, insulin resistance and type 2 diabetes

Our group investigates the molecular basis of onset and progression of obesity, insulin resistance and type 2 diabetes. In a genetics approach, polygenic mouse models are used to identify novel susceptibility genes and relevant pathomechanisms for obesity and diabetes. Our group focuses on the molecular analysis of insulin action with respect to glucose and lipid metabolism, gene/gene and gene/environment interactions, and associated metabolic impairments of insulin-target tissues in diabetes.

Current aims

  • Identification of susceptibility genes and gene/environment interactions in polygenic mouse models for insulin resistance and diabetes
  • Function of the TBC1D-family GAPs and GEFs in lipid and glucose metabolism
  • Pathogenesis of insulin resistance

Our group closely collaborates with the Research Group Energy Metabolism of the Institute for Clinical Diabetology and the Research Group Beta Cell Defects of the Institute for Vascular and Islet Cell Biology.


Selected Publications

Teaching activities at Heinrich Heine University Düsseldorf

National Cooperations

  • Partner and associated partner of the German Center for Diabetes Research (DZD e. V.)
  • Max-Planck-Institut für molekulare Genetik (MPIMG) Berlin: Dr. Ralf Herwig

International Cooperations

  • Lund University, SE: Prof. Dr. Ola Hansson
  • Novo Nordisk Foundation Center for Basic Metabolic Research and University of Copenhagen, DK: Prof. Dr. Torben Hansen, Prof. Dr. Jørgen Wojtaszewski
  • Universitat Autònoma de Barcelona (UAB), ES: Prof. Dr. Fatima Bosch
  • University of Eastern Finland, NO: Prof. Dr. Markku Laakso
  • University of Oslo, NO: Prof. Dr. Hege Thoresen
  • University of Wisconsin, USA: Prof. Dr. Alan D. Attie
  • University of Strathclyde, UK: Prof. Gwyn Gould
  • Monash University, AUS: Dr. Georg Ramm
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