Research Group Clinical Research Center

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Beispiel von einer Untersuchung im klinischen Studienzentrums

The Research Group Clinical Research Center focuses on clinical-experimental studies of diabetes and its sequelae in humans.

Main research activities are

  • The detailed clinical, metabolic and immunologic characterisation of individuals with diabetes in observational studies like the German Diabetes Center (GDC) Study
  • The analysis of the underlying mechanisms in the development of insulin resistance and type 2 diabetes
  • The modification of the disease course of both type 1 and type 2 diabetes and its complications by pharmacological and lifestyle interventions

Research aims

  • What are the mechanisms in the development of diabetes and its complications and what ist he impact of metabolic, immunologic and diet-related factors?
  • The the disease course and the development of complications modifiable by interventions and are the effective and long-lasting?

Previous studies analysed whether the disease course of patients with type 1 or type 2 diabetes can be influenced by immune interventions, lifestyle changes and pharmacological interventions (phase I - IV studies). Besides regular clinical examinations (anthropometry, laboratory analysis and physical examination), numerous specialised analysis methods are available, such as Clamp-studies, ivGTT, endothelial function (FMD) and Intima-Media-Thickness (IMT), indirect calorimetry, spiroergometry, immunological characterization as well as biopsies and microdialysis of subcutaneous adipose tissue.

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Selected Publications


  • Heinrich-Heine-Universität Düsseldorf, Institut für Pharmakologie und Klinische Phahrmakologie: T. Hohlfeld
  • Universität Giessen, Klinik für Psychosomatische Medizin und Psychotherapie: J. Kruse
  • Forschungsinstitut der Diabetes Akademie Mergentheim (FIDAM): B. Kulzer, N. Hermanns
  • Heinrich-Heine-Universität Düsseldorf, Klinik für Allgemeine Pädiatrie: T. Meissner, E. Mayatepek
  • Koordinierungszentrum für Klinische Studien, Heinrich-Heine Universität Düsseldorf: C. Ohmann

Project Funding

  • Bundesministerium für Bildung und Forschung (BMBF)
  • Deutsches Zentrum für Diabetesforschung (DZD e. V.)
  • European Commission (EC)
  • European Foundation for the Study of Diabetes (EFSD)
  • Industry Funds (z. B. Takeda Pharma, MDS Services, Pfizer)

Teaching Activities at Heinrich-Heine University Düsseldorf

  • Lecture - Immune Biology with a clinical aspect for medical students (Burkart)
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