Diabetes mellitus often occurs in comorbidity with other diseases. In addition to somatic comorbidities such as cardiovascular diseases, blindness and kidney damage, mental health comorbidities are of relevance, in particular depression. Comorbid depression in people with diabetes mellitus is associated with poorer quality of life, higher health care costs, an increased risk of developing diabetes-related complications, and increased mortality rates. There are limited possible explanations for the comorbid occurrence of diabetes and mental diseases. Longitudinal studies as well as studies that analyze potential explanatory factors in detail, are still scarce and partly present contradictory results. Up to now, few studies have investigated the risk of depression in people with undiagnosed diabetes. Conducted studies at the ISE found there to be no increased risk of depression in this group after 5 years. There are currently no studies with longer observational periods.
The aim is to analyze the link between diagnosed and undiagnosed diabetes and the occurrence of depression.
The basis of the data is the 10-year follow-up of the population-based Heinz Nixdorf Recall Study (HNR). Our study will investigate the risk of developing depressive symptoms in participants with diabetes mellitus diagnosed at baseline and undiagnosed prior to baseline compared to participants without diabetes at baseline. The HNR data from the baseline survey and the follow-up studies (5 and 10 years) will be used for this purpose. Multivariate regression analysis will be used.
Icks, A., Kruse, J., Dragano, N., Broecker-Preuss, M., Slomiany, U. et al. (2008). Are symptoms of depression more common in diabetes? Results from the Heinz Nixdorf Recall study. Diabetic Medicine, 25: 1330–1336.
Icks, A., Albers, B., Haastert, B., Pechlivanis, S., Bokhof, B., Slomiany, U., ... & Herder, C. (2013). Diabetes incidence does not differ between subjects with and without high depressive symptoms—5‐year follow‐up results of the Heinz Nixdorf Recall Study. Diabetic Medicine, 30(1), 65–69.
Icks, A., Albers, B., Haastert, B., Pechlivanis, S., Pundt, N., Slomiany, U., & Nowotny, B. (2013). Risk for high depressive symptoms in diagnosed and previously undetected diabetes: 5-year follow-up results of the Heinz Nixdorf Recall study. PloS one, 8(2), e56300.