Univ.-Prof. Dr. Michael Roden

Selected Publications

• Ziegler D, Bönhof GJ, Strom A, Straßburger K, Karusheva Y, Szendroedi J, Roden M for the GDS Group 2021. Progression and regression of nerve fibre pathology and dysfunction early in diabetes over 5 years. Brain. 144: 3251-3263. https://doi.org/10.1093/brain/awab330
• Kahl S, Gancheva S, Strassburger K, Herder C, Machann J, Katsuyama H, Kabisch S, Henkel E, Kopf S, Lagerpusch M, Kantartzis K, Kupriyanova Y, Markgraf D, Kössler T, Knebel B, Wolkersdorfer M, Kuss O, Hwang JH, Bornstein SR, Kasperk C, Stefan N, Pfeiffer A, Birkenfeld AL, Roden M 2020. Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial. Diabetes Care. 43: 298-305. https://doi.org/10.2337/dc19-0641
• Roden M, Shulman GI 2019. The integrative biology of type 2 diabetes. Nature. 576: 51-60. https://doi.org/10.1038/s41586-019-1797-8
• Gancheva S, Ouni M, Jelenik T, Koliaki C, Szendroedi J, Toledo FGS, Markgraf DF, Pesta DH, Mastrototaro L, De Filippo E, Herder C, Jähnert M, Weiss J, Strassburger K, Schlensak M, Schürmann A, Roden M 2019. Dynamic changes of muscle insulin sensitivity after metabolic surgery. Nat Commun. 10. https://doi.org/10.1038/s41467-019-12081-0
• Gancheva S, Jelenik T, Álvarez-Hernández E, Roden M 2018. Interorgan Metabolic Crosstalk in Human Insulin Resistance. Physiol Rev. 98: 1371-1415. https://doi.org/10.1152/physrev.00015.2017
• Apostolopoulou M, Gordillo R, Koliaki C, Gancheva S, Jelenik T, De Filippo E, Herder C, Markgraf D, Jankowiak F, Esposito I, Schlensak M, Scherer PE, Roden M 2018. Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis. Diabetes Care. 41: 1235-1243. https://doi.org/10.2337/dc17-1318
• Álvarez-Hernández E, Kahl S, Seelig A, Begovatz P, Irmler M, Kupriyanova Y, Nowotny B, Nowotny P, Herder C, Barosa C, Carvalho F, Rozman J, Neschen S, Jones JG, Beckers J, de Angelis MH, Roden M 2017. Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. J Clin Invest. 127: 695-708. https://doi.org/10.1172/JCI89444
• Gancheva S, Koliaki C, Bierwagen A, Nowotny P, Heni M, Fritsche A, Häring H-U, Szendroedi J, Roden M 2015. Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans. Diabetes. 64: 1966-75. https://doi.org/10.2337/db14-0892
• Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, Schlensak M, Roden M 2015. Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab. 21: 739-46. https://doi.org/10.1016/j.cmet.2015.04.004
• Szendroedi J, Yoshimura T, Phielix E, Koliaki C, Marcucci M, Zhang D, Jelenik T, Müller J, Herder C, Nowotny P, Shulman GI, Roden M 2014. Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans. Proc Natl Acad Sci U S A. 111: 9597-602. https://doi.org/10.1073/pnas.1409229111
• Roden M, Price T, Perseghin G, Petersen K, Rothman D, Cline GW, Shulman GI 1996. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest. 97: 2859-2865. https://doi.org/10.1172/JCI118742