{"id":24723,"date":"2025-03-05T11:04:50","date_gmt":"2025-03-05T10:04:50","guid":{"rendered":"https:\/\/ddz.de\/?page_id=24723"},"modified":"2025-03-05T15:58:06","modified_gmt":"2025-03-05T14:58:06","slug":"unit_name-foojunior-reaearch-group-crosstalk-unit_id7406167","status":"publish","type":"page","link":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-biochemistry-and-pathobiochemistry\/unit_name-foojunior-reaearch-group-crosstalk-unit_id7406167\/","title":{"rendered":"Junior Research Group Crosstalk"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_single_image source=&#8221;featured_image&#8221; img_size=&#8221;full&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<h2>The research group Crosstalk explores how inter-tissue communication impacts energy balance and metabolic health.<\/h2>\n<p>Proteins are secreted from various cells of tissues and mediate inter-organ crosstalk. They can exert beneficial or detrimental effects,\u00a0based on their concentration and context. The composition of secreted proteins, collectively known as the protein \u201csecretome\u201d changes with different stimuli, such as in exercise, diet changes, and different diseases. These changes in the composition of the secretome can have severe effects on the whole body.<\/p>\n<p>Skeletal muscle and adipose tissue are key secretory organs. Exercise-induced myokines from skeletal muscle have beneficial effects and can reduce disease risks. Obesity-induced adipokines from adipose tissue often promote inflammation, which contributes to the development of obesity-related comorbidities. Thus, identification of previously unknown effector myokines and adipokines is crucial, not only to find specific biomarkers for diseases and therapeutic targets but also to understand the basic molecular mechanisms of how tissues communicate with each other. However, to date, many myokines and adipokines remain undiscovered. This is due to methodological limitations based on the low abundance of many of these proteins. Previously, we have developed a proteomics-based technique that allows for the identification of novel, low abundant myokines and adipokines in the extracellular fluid of muscle and adipose tissue. We are utilizing this technique to find unknown myokines and adipokines and subsequently study their molecular signaling cascades. By understanding how these proteins function and influence whole body metabolism, we aim at contributing to the development of new treatments for obesity, diabetes, and related comorbidities.<\/p>\n<p>Specifically, we are focusing on the following aims:<\/p>\n<ul>\n<li><em>Adipokines and their role in high fat diet-induced adipose tissue inflammation (1).<\/em><\/li>\n<li><em>Exercise-induced myokines and their beneficial effects on obesity and diabetes (2). <\/em><\/li>\n<li><em>Molecular mechanisms of the novel myokine PSAP in adipose tissue maintenance (3). <\/em><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row el_class=\"distance-top-small\"][vc_column][vc_tta_tour tab_position=\"right\" active_section=\"1\"][vc_tta_section i_icon_fontawesome=\"fa fa-users\" add_icon=\"true\" title=\"Team\" tab_id=\"1557219375391-43fad21d-8602\"][vc_column_text]<\/p>\n<h2>Team<\/h2>\n<p>[\/vc_column_text][vc_column_text css=\"\"]<div class=\" pure-data shortcodes color-links\"><div class=\"visitenkarten-container\"><div class=\"visitenkarte\">\r\n\t\t\t\t\t<div class=\"inner\">\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"portrait\" style=\"background-image:url(https:\/\/api.ddz.de\/file\/get\/ab13412e83614e6b19b567345c5e9797536ba92eba652499b3e4f43fe015520b.png)\" title=\"Portrait image of Melanie  Mittenb\u00fchler, Dr.\"><\/div>\r\n\t\t\t\t\t\t\r\n\r\n\t\t\t\t\t\t<div class=\"left\">\r\n\t\t\t\t\t\t\t<div class=\"name mb-3\">Melanie  Mittenb\u00fchler, Dr.<\/div>\r\n\t\t\t\t\t\t\t<div class=\"units-roles mt-2 clear-first\"><div class=\"roles-and-unit mt-2 clear-first\"><div class=\"roles hyphens\"><span class=\"role hyphens mb-1 clear-last\">Head<\/span><\/div><div class=\"orgaunit hyphens\">Junior Research Group Crosstalk<\/div><\/div><\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t<div class=\"contacts mt-4\">\r\n\t\t\t\t\t\t\t\t<div class=\"email mt-2\"><a href=\"mailto:melanie.mittenbuehler@ddz.de\" title=\"Send e-mail to Melanie  Mittenb\u00fchler, Dr.\"><i class=\"fa fa-envelope\"><\/i> melanie.mittenbuehler@ddz.de<\/a><\/div>\r\n\t\t\t\t\t\t\t\t<div class=\"phones mt-2\"><div class=\"phone mt-1 clear-first\"><i class=\"fa fa-phone\"><\/i>+49 211 3382-625<\/div><\/div>\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t<div class=\"author-link mt-4\"><a href=\"\/author\/?id=7227436#melanie-mittenbuhler-dr\" title=\"View selected publications of Melanie  Mittenb\u00fchler, Dr.\"><i class=\"fa fa-user\"><\/i>Selected publications<\/a><\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div><\/div><div class=\"persons-container\"><ul class=\"special table tr-pad td-pad-l tr-sep td-sep\"><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Alessandro Minisgallo, M. Sc.<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:alessandro.minisgallo@ddz.de\" title=\"E-Mail senden an Alessandro Minisgallo, M. Sc.\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Maurice Sagorsky, M.Sc.<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:maurice.sagorsky@ddz.de\" title=\"E-Mail senden an Maurice Sagorsky, M.Sc.\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Sara Stanic, Dr.<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:sara.stanic@ddz.de\" title=\"E-Mail senden an Sara Stanic, Dr.\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><\/ul><\/div><\/div>[\/vc_column_text][\/vc_tta_section][vc_tta_section i_icon_fontawesome=\"\" add_icon=\"true\" title=\"Selected Publications\" tab_id=\"1557219386270-21db6446-ffce\"][vc_column_text css=\"\"]<\/p>\n<h2>Selected Publications<\/h2>\n<p>[\/vc_column_text][vc_column_text css=\"\"]<div class=\" pure-data shortcodes color-links\"><ul class=\"publications special color-links\"><li>Sprenger H-G, Mittenb\u00fchler MJ, Sun Y, Van Vranken JG, Schindler S, Jayaraj A, Khetarpal SA, Smythers AL, Vargas-Castillo A, Puszynska AM, Spinelli JB, Armani A, Kunchok T, Ryback B, Seo H-S, Song K, Sebastian L, O'Young C, Braithwaite C, Dhe-Paganon S, Burger N, Mills EL, Gygi SP, Paulo JA, Arthanari H, Chouchani ET, Sabatini DM, Spiegelman BM 2025. <span class=\"title\" lang=\"en\">Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST.<\/span> Cell metabolism. 37: 857-869.e9. <a target=\"_blank\" href=\"https:\/\/doi.org\/doi.org\/10.1016\/j.cmet.2025.01.024\" title=\"Open the website of the publication &#187;Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST&#171;\">https:\/\/doi.org\/doi.org\/10.1016\/j.cmet.2025.01.024<\/a><\/li><li>Burger N, Mittenb\u00fchler MJ, Xiao H, Shin S, Wei SM, Henze EK, Schindler S, Mehravar S, Wood DM, Petrocelli JJ, Sun Y, Sprenger H-G, Latorre-Muro P, Smythers AL, Bozi LHM, Darabedian N, Zhu Y, Seo H-S, Dhe-Paganon S, Che J, Chouchani ET 2025. <span class=\"title\" lang=\"en\">The human zinc-binding cysteine proteome.<\/span> Cell. 188: 832-850.e27. <a target=\"_blank\" href=\"https:\/\/doi.org\/doi.org\/10.1016\/j.cell.2024.11.025\" title=\"Open the website of the publication &#187;The human zinc-binding cysteine proteome&#171;\">https:\/\/doi.org\/doi.org\/10.1016\/j.cell.2024.11.025<\/a><\/li><li>Mittenb\u00fchler M, Smythers AL, Spiegelman BM 2024. <span class=\"title\" lang=\"en\">Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues.<\/span> Methods Cell Biology. <a target=\"_blank\" href=\"https:\/\/doi.org\/doi.org\/10.1016\/bs.mcb.2024.08.004\" title=\"Open the website of the publication &#187;Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues&#171;\">https:\/\/doi.org\/doi.org\/10.1016\/bs.mcb.2024.08.004<\/a><\/li><li>Ducommun S, Jannig PR, Cervenka I, Murgia M, Mittenb\u00fchler MJ, Chernogubova E, Dias JM, Jude B, Correia JC, Van Vranken JG, Ocana-Santero G, Porsmyr-Palmertz M, McCann Haworth S, Mart\u00ednez-Redondo V, Liu Z, Carlstr\u00f6m M, Mann M, Lanner JT, Teixeira AI, Maegdefessel L, Spiegelman BM, Ruas JL 2024. <span class=\"title\" lang=\"en\">Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition.<\/span> Molecular Metabolism. 82: 101912. <a target=\"_blank\" href=\"https:\/\/doi.org\/doi.org\/10.1016\/j.molmet.2024.101912\" title=\"Open the website of the publication &#187;Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition&#171;\">https:\/\/doi.org\/doi.org\/10.1016\/j.molmet.2024.101912<\/a><\/li><li>A M, Wales TE, Zhou H, Draga-Colet\u0103 S-V, Gorgulla C, Blackmore KA, Mittenb\u00fchler MJ, Kim CR, Bogoslavski D, Zhang Q, Wang Z-F, Jedrychowski MP, Seo H-S, Song K, Xu AZ, Sebastian L, Gygi SP, Arthanari H, Dhe-Paganon S, Griffin PR, Engen JR, Spiegelman BM 2023. <span class=\"title\" lang=\"en\">Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90\u03b1.<\/span> Molecular cell. 83: 1903-1920.e12. <a target=\"_blank\" href=\"https:\/\/doi.org\/doi.org\/10.1016\/j.molcel.2023.05.008\" title=\"Open the website of the publication &#187;Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90\u03b1&#171;\">https:\/\/doi.org\/doi.org\/10.1016\/j.molcel.2023.05.008<\/a><\/li><li>Mittenb\u00fchler MJ, Jedrychowski MP, Van Vranken JG, Sprenger H-G, Wilensky S, Dumesic PA, Sun Y, Tartaglia A, Bogoslavski D, A M, Xiao H, Blackmore KA, Reddy A, Gygi SP, Chouchani ET, Spiegelman BM 2023. <span class=\"title\" lang=\"en\">Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues.<\/span> Cell metabolism. 35: 535-549.e7. <a target=\"_blank\" href=\"https:\/\/doi.org\/doi.org\/10.1016\/j.cmet.2022.12.014\" title=\"Open the website of the publication &#187;Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues&#171;\">https:\/\/doi.org\/doi.org\/10.1016\/j.cmet.2022.12.014<\/a><\/li><li>Kam T-I, Park H, Chou S-C, Van Vranken JG, Mittenb\u00fchler MJ, Kim H, A M, Choi YR, Biswas D, Wang J, Shin Y, Loder A, Karuppagounder SS, Wrann CD, Dawson VL, Spiegelman BM, Dawson TM 2022. <span class=\"title\" lang=\"en\">Amelioration of pathologic \u03b1-synuclein-induced Parkinson's disease by irisin.<\/span> Proceedings of the National Academy of Sciences of the United States of America. 119: e2204835119. <a target=\"_blank\" href=\"https:\/\/doi.org\/doi.org\/10.1073\/pnas.2204835119\" title=\"Open the website of the publication &#187;Amelioration of pathologic \u03b1-synuclein-induced Parkinson&#039;s disease by irisin&#171;\">https:\/\/doi.org\/doi.org\/10.1073\/pnas.2204835119<\/a><\/li><li>Mittenb\u00fchler MJ, Saedler K, Nolte H, Kern L, Zhou J, Qian S-B, Meder L, Ullrich RT, Br\u00fcning JC, Wunderlich FT 2020. <span class=\"title\" lang=\"en\">Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in\u00a0vivo.<\/span> Molecular Metabolism. 42: 101085. <a target=\"_blank\" href=\"https:\/\/doi.org\/doi.org\/10.1016\/j.molmet.2020.101085\" title=\"Open the website of the publication &#187;Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in\u00a0vivo&#171;\">https:\/\/doi.org\/doi.org\/10.1016\/j.molmet.2020.101085<\/a><\/li><li>Kern L, Mittenb\u00fchler MJ, Vesting AJ, Ostermann AL, Wunderlich CM, Wunderlich FT 2018. <span class=\"title\" lang=\"en\">Obesity-Induced TNF\u03b1 and IL-6 Signaling: The Missing Link between Obesity and Inflammation\u2014Driven Liver and Colorectal Cancers.<\/span> Cancers. 11. <a target=\"_blank\" href=\"https:\/\/doi.org\/doi.org\/10.3390\/cancers11010024\" title=\"Open the website of the publication &#187;Obesity-Induced TNF\u03b1 and IL-6 Signaling: The Missing Link between Obesity and Inflammation\u2014Driven Liver and Colorectal Cancers&#171;\">https:\/\/doi.org\/doi.org\/10.3390\/cancers11010024<\/a><\/li><li>Mittenb\u00fchler MJ, Sprenger H-G, Gruber S, Wunderlich CM, Kern L, Br\u00fcning JC, Wunderlich FT 2018. <span class=\"title\" lang=\"en\">Hepatic leptin receptor expression can partially\u00a0compensate for IL-6R\u03b1 deficiency in\u00a0DEN-induced hepatocellular carcinoma.<\/span> Molecular Metabolism. 17: 122-133. <a target=\"_blank\" href=\"https:\/\/doi.org\/doi.org\/10.1016\/j.molmet.2018.08.010\" title=\"Open the website of the publication &#187;Hepatic leptin receptor expression can partially\u00a0compensate for IL-6R\u03b1 deficiency in\u00a0DEN-induced hepatocellular carcinoma&#171;\">https:\/\/doi.org\/doi.org\/10.1016\/j.molmet.2018.08.010<\/a><\/li><\/ul><\/div>[\/vc_column_text][\/vc_tta_section][\/vc_tta_tour][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_single_image source=&#8221;featured_image&#8221; img_size=&#8221;full&#8221;][vc_column_text css=&#8221;&#8221;] Proteins are secreted from various cells of tissues and mediate inter-organ crosstalk. They can exert beneficial or detrimental effects,\u00a0based on their concentration and context. The composition [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24719,"parent":18121,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[195],"tags":[],"class_list":["post-24723","page","type-page","status-publish","has-post-thumbnail","hentry","category-institute-for-clinical-biochemistry-and-pathobiochemistry"],"acf":{"ddz-icon":false,"attachments":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Junior Research Group Crosstalk - Deutsches Diabetes-Zentrum (DDZ)<\/title>\n<meta name=\"description\" content=\"The research group Crosstalk explores how inter-tissue communication impacts energy balance and metabolic health.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-biochemistry-and-pathobiochemistry\/unit_name-foojunior-reaearch-group-crosstalk-unit_id7406167\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[unit_name foo=&quot;Junior Reaearch-Group Crosstalk&quot; unit_id=&quot;7406167&quot;\/] - 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