{"id":20188,"date":"2020-03-03T13:05:46","date_gmt":"2020-03-03T12:05:46","guid":{"rendered":"https:\/\/2020.ddz.de\/research\/institute-for-clinical-diabetology\/unit_name-fooarbeitsgruppe-nephropathie-unit_id1789066\/"},"modified":"2025-11-13T14:55:09","modified_gmt":"2025-11-13T13:55:09","slug":"nephropathy","status":"publish","type":"page","link":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/nephropathy\/","title":{"rendered":"Research Group Nephropathy"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_single_image source=&#8221;featured_image&#8221; img_size=&#8221;full&#8221;][vc_column_text]<\/p>\n<h2>The research group for nephropathy deals with the kidney-specific long-term complications of diabetes mellitus.<\/h2>\n<p>Diabetic nephropathy is the leading cause for end-stage renal disease, which requires dialysis or renal transplantation. Oxidative stress plays a critical role in the development and progression of diabetic nephropathy. Oxidative stress is created by reactive oxygen species (ROS), which are being mainly produced by mitochondria and NADPH oxidases (NOXs) in renal cells under pathological conditions, and contribute to mitochondrial functional impairments, DNA damage and the induction of inflammatory pathways. These lead to structural and functional changes in the renal tissue, and thus to the development of diabetic nephropathy. The main focus of the research group for nephropathy is the development of innovative therapeutic strategies to inhibit the overproduction of renal ROS that would avoid pathological changes in the kidney, and thus lead to a prevention of the development and progression of diabetic nephropathy.[\/vc_column_text][\/vc_column][\/vc_row][vc_row el_class=\"distance-top-small\"][vc_column][vc_tta_tour tab_position=\"right\" active_section=\"1\"][vc_tta_section i_icon_fontawesome=\"fa fa-users\" add_icon=\"true\" title=\"Team\" tab_id=\"1557219375391-43fad21d-8602\"][vc_column_text]<\/p>\n<h2>Team<\/h2>\n<p>[\/vc_column_text][vc_column_text]<div class=\" pure-data shortcodes color-links\"><div class=\"visitenkarten-container\"><div class=\"visitenkarte\">\r\n\t\t\t\t\t<div class=\"inner\">\r\n\t\t\t\t\t\t\r\n\r\n\t\t\t\t\t\t<div class=\"left\">\r\n\t\t\t\t\t\t\t<div class=\"name mb-3\">Prof. Dr. med. Karin A.M. Jandeleit-Dahm, MD, PhD, FRACP<\/div>\r\n\t\t\t\t\t\t\t<div class=\"units-roles mt-2 clear-first\"><div class=\"roles-and-unit mt-2 clear-first\"><div class=\"roles hyphens\"><span class=\"role hyphens mb-1 clear-last\">Head<\/span><\/div><div class=\"orgaunit hyphens\">Research Group Nephropathy<\/div><\/div><\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t<div class=\"additional-infos mt-3\">Awarded with the Leibniz Chair<\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t<div class=\"contacts mt-4\">\r\n\t\t\t\t\t\t\t\t<div class=\"email mt-2\"><a href=\"mailto:karin.jandeleit-dahm@monash.edu\" title=\"Send e-mail to Prof. Dr. med. Karin A.M. Jandeleit-Dahm, MD, PhD, FRACP\"><i class=\"fa fa-envelope\"><\/i> karin.jandeleit-dahm@monash.edu<\/a><\/div>\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t<div class=\"author-link mt-4\"><a href=\"\/author\/?id=1789086#prof-dr-med-karin-am-jandeleit-dahm-md-phd-fracp\" title=\"View selected publications of Prof. Dr. med. Karin A.M. Jandeleit-Dahm, MD, PhD, FRACP\"><i class=\"fa fa-user\"><\/i>Selected publications<\/a><\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div><div class=\"visitenkarte\">\r\n\t\t\t\t\t<div class=\"inner\">\r\n\t\t\t\t\t\t\r\n\r\n\t\t\t\t\t\t<div class=\"left\">\r\n\t\t\t\t\t\t\t<div class=\"name mb-3\">Dr. med. Jaroslawna Meister<\/div>\r\n\t\t\t\t\t\t\t<div class=\"units-roles mt-2 clear-first\"><div class=\"roles-and-unit mt-2 clear-first\"><div class=\"roles hyphens\"><span class=\"role hyphens mb-1 clear-last\">Deputy head<\/span><\/div><div class=\"orgaunit hyphens\">Research Group Nephropathy<\/div><\/div><\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t<div class=\"contacts mt-4\">\r\n\t\t\t\t\t\t\t\t<div class=\"email mt-2\"><a href=\"mailto:jaroslawna.meister@ddz.de\" title=\"Send e-mail to Dr. med. Jaroslawna Meister\"><i class=\"fa fa-envelope\"><\/i> jaroslawna.meister@ddz.de<\/a><\/div>\r\n\t\t\t\t\t\t\t\t<div class=\"phones mt-2\"><div class=\"phone mt-1 clear-first\"><i class=\"fa fa-phone\"><\/i>+49 211 3382-406<\/div><\/div>\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div><\/div><div class=\"persons-container\"><ul class=\"special table tr-pad td-pad-l tr-sep td-sep\"><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Ara Aboolian, M. Sc.<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:ara.aboolian@ddz.de\" title=\"E-Mail senden an Ara Aboolian, M. Sc.\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Ayesha Ahmad<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:ayesha.ahmad@ddz.de\" title=\"E-Mail senden an Ayesha Ahmad\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Hannah Kordubel<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:hannah.kordubel@ddz.de\" title=\"E-Mail senden an Hannah Kordubel\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Shreya Yogesh Mahajan<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:shreya.mahajan@ddz.de\" title=\"E-Mail senden an Shreya Yogesh Mahajan\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Niloofar Salehzadeh<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:niloofar.salehzadeh@ddz.de\" title=\"E-Mail senden an Niloofar Salehzadeh\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><\/ul><\/div><\/div>[\/vc_column_text][\/vc_tta_section][vc_tta_section i_icon_fontawesome=\"fa fa-leanpub\" add_icon=\"true\" title=\"Selected Publications\" tab_id=\"1557219386270-21db6446-ffce\"][vc_column_text]<\/p>\n<h2>Selected Publications<\/h2>\n<p>[\/vc_column_text][vc_column_text]<div class=\" pure-data shortcodes color-links\"><ul class=\"publications special color-links\"><li>Jha JC, Dai A, Holterman CE, Cooper ME, Touyz RM, Kennedy CR, Jandeleit-Dahm KAM 2019. <span class=\"title\" lang=\"en\">Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse.<\/span> Diabetologia. 62: 1712-1726. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1007\/s00125-019-4924-z\" title=\"Open the website of the publication &#187;Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse&#171;\">https:\/\/doi.org\/10.1007\/s00125-019-4924-z<\/a><\/li><\/ul><\/div>[\/vc_column_text][\/vc_tta_section][\/vc_tta_tour][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_single_image source=&#8221;featured_image&#8221; img_size=&#8221;full&#8221;][vc_column_text] Diabetic nephropathy is the leading cause for end-stage renal disease, which requires dialysis or renal transplantation. Oxidative stress plays a critical role in the development and progression [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":20440,"parent":17754,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[193],"tags":[],"class_list":["post-20188","page","type-page","status-publish","has-post-thumbnail","hentry","category-institute-for-clinical-diabetologie"],"acf":{"ddz-icon":false,"attachments":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research Group Nephropathy - Deutsches Diabetes-Zentrum (DDZ)<\/title>\n<meta name=\"description\" content=\"The research group for nephropathy deals with the kidney-specific long-term complications of diabetes mellitus.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/nephropathy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[unit_name foo=&quot;Research Group Nephropathy&quot; unit_id=&quot;1789066&quot;\/] - 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