{"id":18519,"date":"2019-11-19T15:45:11","date_gmt":"2019-11-19T14:45:11","guid":{"rendered":"https:\/\/2020.ddz.de\/?page_id=18519"},"modified":"2020-03-03T15:34:25","modified_gmt":"2020-03-03T14:34:25","slug":"research-group-genomics","status":"publish","type":"page","link":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-biochemistry-and-pathobiochemistry\/research-group-genomics\/","title":{"rendered":"Research Group Genomics"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_single_image source=&#8221;featured_image&#8221; img_size=&#8221;full&#8221;][vc_column_text]<\/p>\n<h2>Metabolic risk factors at the genetic level\u00a0<\/h2>\n<p>Metabolic risk factors, such as arterial hypertension, obesity, diabetes mellitus type 2 or glucose intolerance as well as disorders of lipid metabolism are multifactorial polygenic diseases that can occur cumulatively in an individual. The link for this clinical clustering of risk factors lies on the genetic level, whereby the pathogenesis of such multifactorial diseases is directly influenced by multiple environmental factors, called \u201clifestyle\u201d, depending on the individual genetic predisposition. Genetics and lifestyle interaction can be caused by changes in short-, medium- and long-term gene regulation in direct response to a physiological stimulus in the sense of physiological memory or even \u201cphysiological inheritance\u201d.<\/p>\n<p>The integration of the data of a phenotype with the underlying genotype and its specific reaction to environmental influences is regarded as systems biology and is an essential content of translational medicine. It is not yet clear whether the numerous relevant gene loci have the same meaning or whether there are dominant gene loci. An established approach in polygenic multifactorial diseases is to characterize defects of identified signaling disorders in genetically defined patients and then to define the role of these newly identified gene loci in common manifestations.<\/p>\n<p>The main focus of the research group is to investigate complex molecular processes in the development and progression of polygenic diseases as well as their alteration by environmental influences and to use genetic analyses as part of the research project. Besides the investigation of known target genes, the identification and subsequent validation of new candidate genes associated with e.g. arterial hypertension, obesity, diabetes mellitus type 2 or glucose intolerance and disorders of lipid metabolism is an essential part of the research.<\/p>\n<h2>Aims of research<\/h2>\n<ul>\n<li>To investigate complex molecular processes in the development and progression of polygenic diseases and their alteration by environmental influences and to make genetic analyses available as part of the research project<\/li>\n<li>Investigation of known target genes and identification and subsequent validation of new candidate genes associated with e.g. arterial hypertension, obesity, diabetes mellitus type 2 or glucose intolerance and disorders of lipid metabolism<\/li>\n<li>The working group also provides support in the field of DNA (sequencing, genotyping) and expression analysis (transcriptome analysis, methylation)<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row el_class=\"distance-top-small\"][vc_column][vc_tta_tour tab_position=\"right\" active_section=\"1\"][vc_tta_section i_icon_fontawesome=\"fa fa-users\" add_icon=\"true\" title=\"Team\" tab_id=\"1557219375391-43fad21d-8602\"][vc_column_text]<\/p>\n<h2>Team<\/h2>\n<p>[\/vc_column_text][vc_column_text]<div class=\" pure-data shortcodes color-links\"><div class=\"visitenkarten-container\"><div class=\"visitenkarte\">\r\n\t\t\t\t\t<div class=\"inner\">\r\n\t\t\t\t\t\t\r\n\r\n\t\t\t\t\t\t<div class=\"left\">\r\n\t\t\t\t\t\t\t<div class=\"name mb-3\">Dr. rer. nat. Birgit Knebel<\/div>\r\n\t\t\t\t\t\t\t<div class=\"units-roles mt-2 clear-first\"><div class=\"roles-and-unit mt-2 clear-first\"><div class=\"roles hyphens\"><span class=\"role hyphens mb-1 clear-last\">Head<\/span><\/div><div class=\"orgaunit hyphens\">Research Group Genomics<\/div><\/div><\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t<div class=\"contacts mt-4\">\r\n\t\t\t\t\t\t\t\t<div class=\"email mt-2\"><a href=\"mailto:birgit.knebel@ddz.de\" title=\"Send e-mail to Dr. rer. nat. Birgit Knebel\"><i class=\"fa fa-envelope\"><\/i> birgit.knebel@ddz.de<\/a><\/div>\r\n\t\t\t\t\t\t\t\t<div class=\"phones mt-2\"><div class=\"phone mt-1 clear-first\"><i class=\"fa fa-phone\"><\/i>+49 211 3382-536<\/div><\/div>\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t<div class=\"author-link mt-4\"><a href=\"\/author\/?id=7185#dr-rer-nat-birgit-knebel\" title=\"View selected publications of Dr. rer. nat. Birgit Knebel\"><i class=\"fa fa-user\"><\/i>Selected publications<\/a><\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div><\/div><\/div>[\/vc_column_text][\/vc_tta_section][vc_tta_section i_icon_fontawesome=\"fa fa-leanpub\" add_icon=\"true\" title=\"Selected Publications\" tab_id=\"1557219386270-21db6446-ffce\"][vc_column_text]<\/p>\n<h2>Selected Publications<\/h2>\n<p>[\/vc_column_text][vc_column_text]<div class=\" pure-data shortcodes color-links\"><ul class=\"publications special color-links\"><li>Nikolic A, Fahlbusch P, Riffelmann N-K, Wahlers N, Jacob S, Hartwig S, Kettel U, Schiller M, Dille M, Al-Hasani H, Kotzka J, Knebel B 2024. <span class=\"title\" lang=\"en\">Chronic stress alters hepatic metabolism and thermodynamic respiratory efficiency affecting epigenetics in C57BL\/6 mice.<\/span> iScience. 27. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.isci.2024.109276\" title=\"Open the website of the publication &#187;Chronic stress alters hepatic metabolism and thermodynamic respiratory efficiency affecting epigenetics in C57BL\/6 mice&#171;\">https:\/\/doi.org\/10.1016\/j.isci.2024.109276<\/a><\/li><li>Nikolic A, Fahlbusch P, Wahlers N, Riffelmann N-K, Jacob S, Hartwig S, Kettel U, Dille M, Al-Hasani H, Kotzka J, Knebel B 2023. <span class=\"title\" lang=\"en\">Chronic stress targets mitochondrial respiratory efficiency in the skeletal muscle of C57BL\/6 mice.<\/span> Cell Mol Life Sci. 80. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1007\/s00018-023-04761-4\" title=\"Open the website of the publication &#187;Chronic stress targets mitochondrial respiratory efficiency in the skeletal muscle of C57BL\/6 mice&#171;\">https:\/\/doi.org\/10.1007\/s00018-023-04761-4<\/a><\/li><li>Fahlbusch P, Nikolic A, Hartwig S, Jacob S, Kettel U, K\u00f6llmer C, Al-Hasani H, Lehr S, M\u00fcller-Wieland D, Knebel B, Kotzka J 2022. <span class=\"title\" lang=\"en\">Adaptation of Oxidative Phosphorylation Machinery Compensates for Hepatic Lipotoxicity in Early Stages of MAFLD.<\/span> Int J Mol Sci. 23. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.3390\/ijms23126873\" title=\"Open the website of the publication &#187;Adaptation of Oxidative Phosphorylation Machinery Compensates for Hepatic Lipotoxicity in Early Stages of MAFLD&#171;\">https:\/\/doi.org\/10.3390\/ijms23126873<\/a><\/li><li>Dille M, Nikolic A, Wahlers N, Fahlbusch P, Jacob S, Hartwig S, Lehr S, Kabra D, Klymenko O, Al-Hasani H, Kotzka J, Knebel B 2022. <span class=\"title\" lang=\"en\">Long-term adjustment of hepatic lipid metabolism after chronic stress and the role of FGF21.<\/span> BBA Molecular Basis of Disease. 1868. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.bbadis.2021.166286\" title=\"Open the website of the publication &#187;Long-term adjustment of hepatic lipid metabolism after chronic stress and the role of FGF21&#171;\">https:\/\/doi.org\/10.1016\/j.bbadis.2021.166286<\/a><\/li><li>Fahlbusch P, Knebel B, H\u00f6rbelt T, Barbosa DM, Nikolic A, Jacob S, Al-Hasani H, Van de Velde F, Van Nieuwenhove Y, M\u00fcller-Wieland D, Lapauw B, Ouwens DM, Kotzka J 2020. <span class=\"title\" lang=\"en\">Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men.<\/span> Int J Mol Sci. 21. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.3390\/ijms21114144\" title=\"Open the website of the publication &#187;Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men&#171;\">https:\/\/doi.org\/10.3390\/ijms21114144<\/a><\/li><li>Barbosa DM, Fahlbusch P, Herzfeld de Wiza D, Jacob S, Kettel U, Al-Hasani H, Kr\u00fcger M, Ouwens DM, Hartwig S, Lehr S, Kotzka J, Knebel B 2020. <span class=\"title\" lang=\"en\">Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis.<\/span> Sci Rep. 10. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41598-020-61886-3\" title=\"Open the website of the publication &#187;Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis&#171;\">https:\/\/doi.org\/10.1038\/s41598-020-61886-3<\/a><\/li><li>H\u00f6rbelt T, Knebel B, Fahlbusch P, Barbosa D, de Wiza DH, Van de Velde F, Van Nieuwenhove Y, Lapauw B, Thoresen GH, Al-Hasani H, M\u00fcller-Wieland D, Ouwens DM, Kotzka J 2019. <span class=\"title\" lang=\"en\">The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver.<\/span> BBA Molecular Basis of Disease. 1865: 2671-2684. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.bbadis.2019.07.008\" title=\"Open the website of the publication &#187;The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver&#171;\">https:\/\/doi.org\/10.1016\/j.bbadis.2019.07.008<\/a><\/li><li>Knebel B, Fahlbusch P, Poschmann G, Dille M, Wahlers N, St\u00fchler K, Hartwig S, Lehr S, Schiller M, Jacob S, Kettel U, M\u00fcller-Wieland D, Kotzka J 2019. <span class=\"title\" lang=\"en\">Adipokinome Signatures in Obese Mouse Models Reflect Adipose Tissue Health and Are Associated with Serum Lipid Composition.<\/span> Int J Mol Sci. 20. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.3390\/ijms20102559\" title=\"Open the website of the publication &#187;Adipokinome Signatures in Obese Mouse Models Reflect Adipose Tissue Health and Are Associated with Serum Lipid Composition&#171;\">https:\/\/doi.org\/10.3390\/ijms20102559<\/a><\/li><li>Knebel B, Fahlbusch P, Dille M, Wahlers N, Hartwig S, Jacob S, Kettel U, Schiller M, Herebian D, Koellmer C, Lehr S, M\u00fcller-Wieland D, Kotzka J 2019. <span class=\"title\" lang=\"en\">Fatty Liver Due to Increased de novo Lipogenesis:<\/span> Alterations in the Hepatic Peroxisomal Proteome. Front Cell Dev Biol. 7. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.3389\/fcell.2019.00248\" title=\"Open the website of the publication &#187;Fatty Liver Due to Increased de novo Lipogenesis&#171;\">https:\/\/doi.org\/10.3389\/fcell.2019.00248<\/a><\/li><li>Goeddeke S, Knebel B, Fahlbusch P, H\u00f6rbelt T, Poschmann G, Van de Velde F, Benninghoff T, Al-Hasani H, Jacob S, Van Niuwenhove Y, Lapauw B, Lehr S, Ouwens DM, Kotzka J 2018. <span class=\"title\" lang=\"en\">CDH13 abundance interferes with adipocyte differentiation and is a novel biomarker for adipose tissue health.<\/span> Int J Obes. 42: 1039-1050. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41366-018-0022-4\" title=\"Open the website of the publication &#187;CDH13 abundance interferes with adipocyte differentiation and is a novel biomarker for adipose tissue health&#171;\">https:\/\/doi.org\/10.1038\/s41366-018-0022-4<\/a><\/li><li>Engelowski E, Schneider A, Franke M, Xu H, Clemen R, Lang A, Baran P, Binsch C, Knebel B, Al-Hasani H, Moll JM, Flo\u00df DM, Lang PA, Scheller J 2018. <span class=\"title\" lang=\"en\">Synthetic cytokine receptors transmit biological signals using artificial ligands.<\/span> Nat Commun. 9. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41467-018-04454-8\" title=\"Open the website of the publication &#187;Synthetic cytokine receptors transmit biological signals using artificial ligands&#171;\">https:\/\/doi.org\/10.1038\/s41467-018-04454-8<\/a><\/li><li>Knebel B, Hartwig S, Jacob S, Kettel U, Schiller M, Passlack W, Koellmer C, Lehr S, M\u00fcller-Wieland D., Kotzka J 2018. <span class=\"title\" lang=\"en\">Inactivation of SREBP-1a phosphorylation prevents fatty liver disease in mice: identification of related signaling pathways by gene expression profiles in liver and proteomes of peroxisomes.<\/span> Int J Mol Sci. 19. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.3390\/ijms19040980\" title=\"Open the website of the publication &#187;Inactivation of SREBP-1a phosphorylation prevents fatty liver disease in mice: identification of related signaling pathways by gene expression profiles in liver and proteomes of peroxisomes&#171;\">https:\/\/doi.org\/10.3390\/ijms19040980<\/a><\/li><li>Jelenik T, Fl\u00f6gel U, \u00c1lvarez-Hern\u00e1ndez E, Scheiber D, Zweck E, Ding Z, Rothe M, Mastrototaro L, Kohlhaas V, Kotzka J, Knebel B, M\u00fcller-Wieland D, Moellendorf S, G\u00f6decke A, Kelm M, Westenfeld R, Roden M, Szendroedi J 2018. <span class=\"title\" lang=\"en\">Insulin Resistance and Vulnerability to Cardiac Ischemia.<\/span> Diabetes. 67: 2695-2702. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.2337\/db18-0449\" title=\"Open the website of the publication &#187;Insulin Resistance and Vulnerability to Cardiac Ischemia&#171;\">https:\/\/doi.org\/10.2337\/db18-0449<\/a><\/li><li><span class=\"title\" lang=\"en\">.<\/span><\/li><\/ul><\/div>[\/vc_column_text][\/vc_tta_section][\/vc_tta_tour][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_single_image source=&#8221;featured_image&#8221; img_size=&#8221;full&#8221;][vc_column_text] Metabolic risk factors, such as arterial hypertension, obesity, diabetes mellitus type 2 or glucose intolerance as well as disorders of lipid metabolism are multifactorial polygenic diseases that [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":18904,"parent":18121,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[195],"tags":[],"class_list":["post-18519","page","type-page","status-publish","has-post-thumbnail","hentry","category-institute-for-clinical-biochemistry-and-pathobiochemistry"],"acf":{"ddz-icon":false,"attachments":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research Group Genomics - Deutsches Diabetes-Zentrum (DDZ)<\/title>\n<meta name=\"description\" content=\"Metabolic risk factors at the genetic level\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-biochemistry-and-pathobiochemistry\/research-group-genomics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[unit_name foo=&quot;Research Group Genomics&quot; unit_id=&quot;1241693&quot;\/] - Deutsches Diabetes-Zentrum (DDZ)\" \/>\n<meta property=\"og:description\" content=\"Metabolic risk factors at the genetic level\u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-biochemistry-and-pathobiochemistry\/research-group-genomics\/\" \/>\n<meta property=\"og:site_name\" content=\"Deutsches Diabetes-Zentrum (DDZ)\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/diabetesinformationsdienst\/\" \/>\n<meta property=\"article:modified_time\" content=\"2020-03-03T14:34:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ddz.de\/wp-content\/uploads\/AG-Genomik_web.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"660\" \/>\n\t<meta property=\"og:image:height\" content=\"528\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@ddz_info\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-biochemistry-and-pathobiochemistry\/research-group-genomics\/\",\"url\":\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-biochemistry-and-pathobiochemistry\/research-group-genomics\/\",\"name\":\"[unit_name foo=\\\"Research Group Genomics\\\" unit_id=\\\"1241693\\\"\/] - 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