{"id":18397,"date":"2019-11-19T11:45:54","date_gmt":"2019-11-19T10:45:54","guid":{"rendered":"https:\/\/2020.ddz.de\/?page_id=18397"},"modified":"2022-10-27T09:28:31","modified_gmt":"2022-10-27T07:28:31","slug":"institute-for-vascular-and-islet-cell-biology","status":"publish","type":"page","link":"https:\/\/ddz.de\/en\/research\/institute-for-vascular-and-islet-cell-biology\/","title":{"rendered":"Institute for Vascular and Islet Cell Biology"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row full_width=&#8221;stretch_row&#8221; full_height=&#8221;yes&#8221; columns_placement=&#8221;bottom&#8221; css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1583494054623{padding-top: 0px !important;padding-bottom: 0px !important;background-image: url(https:\/\/ddz.de\/wp-content\/uploads\/Lammert_cover_4_1280.jpg?id=17934) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}&#8221;][vc_column width=&#8221;1\/2&#8243; css=&#8221;.vc_custom_1558339003167{background-color: #ffffff !important;}&#8221; el_class=&#8221;meta-description-box&#8221;][vc_raw_html]JTVCZGR6aWNvbiU1RCUzQ3NwYW4lMjBjbGFzcyUzRCUyMm1ldGEtZGVzY3JpcHRpb24lMjIlM0UlNUJtZXRhX2Rlc2NyaXB0aW9uJTVEJTNDJTJGc3BhbiUzRQ==[\/vc_raw_html][\/vc_column][vc_column width=&#8221;1\/2&#8243;][\/vc_column][\/vc_row][vc_row el_class=&#8221;distance-top-small&#8221;][vc_column][vc_column_text]<\/p>\n<h2>At the Institute for Vascular and Islet Cell Biology, the pathomechanisms in beta cells and endothelial cells in glucose intolerance and type 2 diabetes are researched.<\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row gap=\"30\" el_class=\"distance-top-small\"][vc_column][vc_column_text]Diabetes is caused by dysfunction of pancreatic islets. The islets are cell aggregates and mainly consist of insulin-secreting pancreatic beta cells. Islet dysfunction affects beta cells in that these cells display a defective insulin secretion, have an increased cell death and undergo dedifferentiation.<\/p>\n<p>Members of the Institute work on these aspects of islet cell biology and were the first to show that a defective vascularization of pancreatic islets causes prediabetes, a first step towards a manifested diabetes mellitus.[\/vc_column_text][vc_column_text]The members could also show that blood vessels provide tissues, including pancreatic islets and liver tissue, with critical growth factors triggered by blood flow and thus affect tissue growth and survival.<\/p>\n<p>Besides working on basic aspects of pancreatic islets and blood vessels, the Institute also works on development of new compounds and therapies to better treat diabetes and its cardiovascular long-term complications.[\/vc_column_text][\/vc_column][\/vc_row][vc_row el_class=\"distance-top\"][vc_column][vc_column_text]<\/p>\n<h2 style=\"text-align: center;\">Managing Directors<\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row el_class=\"distance-top\"][vc_column width=\"1\/2\"][vc_raw_html]JTVCc3RhZmYlMjB1bml0X2lkJTNEJTIyNjA0MCUyMiUyMGdyb3VwJTNEJTIyZXhlY3V0aXZlcyUyMiUyMGNlbnRlciUzRCUyMnRydWUlMjIlMkYlNUQ=[\/vc_raw_html][\/vc_column][vc_column width=\"1\/2\"][vc_raw_html]JTVCc3RhZmYlMjB1bml0X2lkJTNEJTIyNjA0MCUyMiUyMGdyb3VwJTNEJTIyYXNzaXN0YW50cyUyMiUyMGNlbnRlciUzRCUyMnRydWUlMjIlMkYlNUQ=[\/vc_raw_html][\/vc_column][\/vc_row][vc_row][vc_column][vc_raw_html]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[\/vc_raw_html][\/vc_column][\/vc_row][vc_row el_class=\"distance-top\"][vc_column][vc_tta_tour tab_position=\"right\" active_section=\"1\"][vc_tta_section i_icon_fontawesome=\"fa fa-leanpub\" add_icon=\"true\" title=\"Selected Publications\" tab_id=\"1557219386270-21db6446-ffce\"][vc_column_text]<\/p>\n<h2>Selected Publications<\/h2>\n<p>[\/vc_column_text][vc_column_text]<div class=\" pure-data shortcodes color-links\"><ul class=\"publications special color-links\"><li>Scholz O, Hu\u00df E, Otter S, Herebian D, Hamacher A, Levy LM, Hristeva S, Sanz M, Ajani H, Puentes AR, Hoffmann T, Hogeback J, Unger A, Terheyden S, Reina do Fundo M, Dewidar B, Roden M, Lammert E 2023. <span class=\"title\" lang=\"en\">Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety.<\/span> Mol Metab. 75. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.molmet.2023.101775\" title=\"Open the website of the publication &#187;Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety&#171;\">https:\/\/doi.org\/10.1016\/j.molmet.2023.101775<\/a><\/li><li>Pelligra A, Mrugala J, Griess K, Kirschner P, Nortmann O, Bartosinska B, K\u00f6ster A, Krupenko NI, Gebel D, Westhoff P, Steckel B, Eberhard D, Herebian D, Belgardt B-F, Schrader J, Weber APM, Krupenko SA, Lammert E 2023. <span class=\"title\" lang=\"en\">Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism.<\/span> Cell Rep. 42. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.celrep.2023.112703\" title=\"Open the website of the publication &#187;Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism&#171;\">https:\/\/doi.org\/10.1016\/j.celrep.2023.112703<\/a><\/li><li>Griess K, Rieck M, M\u00fcller N, Karsai G, Hartwig S, Pelligra A, Hardt R, Schlegel C, Kuboth J, Uhlemeyer C, Trenkamp S, Jeruschke K, Weiss J, Peifer-Weiss L, Xu W, Cames S, Yi X, Cnop M, Beller M, Stark H, Kondadi AK, Reichert AS, Markgraf D, Wammers M, H\u00e4ussinger D, Kuss O, Lehr S, Eizirik D, Lickert H, Lammert E, Roden M, Winter D, Al-Hasani H, H\u00f6glinger D, Hornemann T, Br\u00fcning JC, Belgardt B-F 2023. <span class=\"title\" lang=\"en\">Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis.<\/span> Nat Cell Biol. 25: 20\u201329 . <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41556-022-01027-2\" title=\"Open the website of the publication &#187;Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis&#171;\">https:\/\/doi.org\/10.1038\/s41556-022-01027-2<\/a><\/li><li>Scholz O, Otter S, Welters A, W\u00f6rmeyer L, Dolen\u0161ek J, Klemen MS, Pohorec V, Eberhard D, Mrugala J, Hamacher A, Koch A, Sanz M, Hoffmann T, Hogeback J, Herebian D, Kl\u00f6cker N, Piechot A, Mayatepek E, Meissner T, Sto\u017eer A, Lammert E 2021. <span class=\"title\" lang=\"en\">Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets.<\/span> Cell Chem Biol. 28: 1474-1488.e7. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.chembiol.2021.05.011\" title=\"Open the website of the publication &#187;Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets&#171;\">https:\/\/doi.org\/10.1016\/j.chembiol.2021.05.011<\/a><\/li><li>Urner S, Planas-Paz L, Hilger LS, Henning C, Branopolski A, Kelly-Goss M, Stanczuk L, Pitter B, Montanez E, Peirce SM, M\u00e4kinen T, Lammert E 2019. <span class=\"title\" lang=\"en\">Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth.<\/span> EMBO J. 38. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.15252\/embj.201899322\" title=\"Open the website of the publication &#187;Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth&#171;\">https:\/\/doi.org\/10.15252\/embj.201899322<\/a><\/li><li>Lorenz L, Axnick J, Buschmann T, Henning C, Urner S, Fang S, Nurmi H, Eichhorst N, Holtmeier R, B\u00f3dis K, Hwang J-H, M\u00fcssig K, Eberhard D, Stypmann J, Kuss O, Roden M, Alitalo K, H\u00e4ussinger D, Lammert E 2018. <span class=\"title\" lang=\"en\">Mechanosensing by \u03b21 integrin induces angiocrine signals for liver growth and survival.<\/span> Nature. 562: 128-132. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41586-018-0522-3\" title=\"Open the website of the publication &#187;Mechanosensing by \u03b21 integrin induces angiocrine signals for liver growth and survival&#171;\">https:\/\/doi.org\/10.1038\/s41586-018-0522-3<\/a><\/li><li>Kragl M, Schubert R, Haiko K, Otter S, Bartosinska B, Jeruschke K, Wei\u00df J, Chen C, Alsteens D, Kuss O, Speier S, Eberhard D, M\u00fcller DJ, Lammert E 2016. <span class=\"title\" lang=\"en\">The biomechanical properties of an epithelial tissue determine the location of its vasculature.<\/span> Nat Commun. 7. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/ncomms13560\" title=\"Open the website of the publication &#187;The biomechanical properties of an epithelial tissue determine the location of its vasculature&#171;\">https:\/\/doi.org\/10.1038\/ncomms13560<\/a><\/li><li>Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen MS, Sto\u017eer A, Wnendt S, Piemonti L, K\u00f6hler M, Ferrer J, Thorens B, Schliess F, Rupnik MS, Heise T, Berggren P-O, Kl\u00f6cker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E 2015. <span class=\"title\" lang=\"en\">Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.<\/span> Nat Med. 21: 363-72. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/nm.3822\" title=\"Open the website of the publication &#187;Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment&#171;\">https:\/\/doi.org\/10.1038\/nm.3822<\/a><\/li><li>Konstantinova I, Nikolova G, Ohara-Imaizumi M, Meda P, Kucera T, Zarbalis K, Wurst W, Nagamatsu S, Lammert E 2007. <span class=\"title\" lang=\"en\">EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets.<\/span> Cell. 129: 359-70. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.cell.2007.02.044\" title=\"Open the website of the publication &#187;EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets&#171;\">https:\/\/doi.org\/10.1016\/j.cell.2007.02.044<\/a><\/li><li>Lammert E, Cleaver O, Melton D 2001. <span class=\"title\" lang=\"en\">Induction of pancreatic differentiation by signals from blood vessels.<\/span> Science (New York, N.Y.). 294: 564-7. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1126\/science.1064344\" title=\"Open the website of the publication &#187;Induction of pancreatic differentiation by signals from blood vessels&#171;\">https:\/\/doi.org\/10.1126\/science.1064344<\/a><\/li><li><span class=\"title\" lang=\"en\">.<\/span><\/li><\/ul><\/div>[\/vc_column_text][\/vc_tta_section][vc_tta_section i_icon_fontawesome=\"fa fa-handshake-o\" add_icon=\"true\" title=\"Cooperations\" tab_id=\"1557308494754-f9a09df0-a4cc\"][vc_column_text]<\/p>\n<h2>Cooperations<\/h2>\n<p>[\/vc_column_text][vc_column_text]<strong>Selected external cooperation partners (alphabetical)<\/strong>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li>Boehringer Ingelheim Pharma GmbH &amp; Co. KG, Biberach: Dr. P. Eickelmann, Dr. S.G. Kauschke, Dr. D. Schumann<\/li>\n<li>Cisanello Krankenhaus, Pisa: Prof. Dr. P. Marchetti, Dr. M. Bugliani<\/li>\n<li>Harvard Medical School, Boston: Prof. Dr. N. Gray, Dr. Q. Liu, Dr. J. Wang<\/li>\n<li>Hubrecht Institut, Utrecht: Prof. Dr. S. Schulte-Merker, Dr. F.L. Bos<\/li>\n<li>Karls-Universit\u00e4t, Prag: Prof. Dr. T. Kucera<\/li>\n<li>Klinik f\u00fcr Allgemeine P\u00e4diatrie, Neonatologie und Kinderkardiologie, Universit\u00e4tsklinikum D\u00fcsseldorf: Dr. D. Herebian, Dr. J. Marquard, Prof. Dr. E. Mayatepek, PD Dr. T. Meissner<\/li>\n<li>MPI f\u00fcr Biochemie, M\u00fcnchen: Prof. Dr. R. F\u00e4ssler, Prof. Dr. M. Mann<\/li>\n<li>Osaka Universit\u00e4t, Osaka: Prof. Dr. S. Tsukita<\/li>\n<li>Profil Institut f\u00fcr Stoffwechselforschung, Neuss: Dr. T. Heise, Prof. Dr. F. Schliess, Dr. A. Stirban<\/li>\n<li>San Raffaele Wissenschaftsinstitut, Mailand: Dr. L. Piemonti<\/li>\n<li>Technische Universit\u00e4t Dresden: Prof. Dr. S. Bornstein, Prof. Dr. G. Breier, Dr. S. Speier<\/li>\n<li>Universit\u00e4t Bremen: Prof. Dr. K. Maedler<\/li>\n<li>University of British Columbia, Vancouver: Prof. Dr. K.M. McNagny, Dr. M.R. Hughes<\/li>\n<li>University of California, San Diego: Prof. Dr. Napoleone Ferrara<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][\/vc_tta_tour][\/vc_column][\/vc_row][vc_row][vc_column][vc_raw_html]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[\/vc_raw_html][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row full_width=&#8221;stretch_row&#8221; full_height=&#8221;yes&#8221; columns_placement=&#8221;bottom&#8221; css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1583494054623{padding-top: 0px !important;padding-bottom: 0px !important;background-image: url(https:\/\/ddz.de\/wp-content\/uploads\/Lammert_cover_4_1280.jpg?id=17934) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}&#8221;][vc_column width=&#8221;1\/2&#8243; css=&#8221;.vc_custom_1558339003167{background-color: #ffffff !important;}&#8221; el_class=&#8221;meta-description-box&#8221;][vc_raw_html]JTVCZGR6aWNvbiU1RCUzQ3NwYW4lMjBjbGFzcyUzRCUyMm1ldGEtZGVzY3JpcHRpb24lMjIlM0UlNUJtZXRhX2Rlc2NyaXB0aW9uJTVEJTNDJTJGc3BhbiUzRQ==[\/vc_raw_html][\/vc_column][vc_column width=&#8221;1\/2&#8243;][\/vc_column][\/vc_row][vc_row el_class=&#8221;distance-top-small&#8221;][vc_column][vc_column_text] At the , the pathomechanisms [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":17934,"parent":17711,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[192],"tags":[],"class_list":["post-18397","page","type-page","status-publish","has-post-thumbnail","hentry","category-research"],"acf":{"ddz-icon":"https:\/\/ddz.de\/wp-content\/uploads\/icon-ivi-1.png","attachments":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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