{"id":18121,"date":"2019-10-31T15:47:57","date_gmt":"2019-10-31T14:47:57","guid":{"rendered":"https:\/\/2020.ddz.de\/?page_id=18121"},"modified":"2022-10-27T09:32:19","modified_gmt":"2022-10-27T07:32:19","slug":"institute-for-clinical-biochemistry-and-pathobiochemistry","status":"publish","type":"page","link":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-biochemistry-and-pathobiochemistry\/","title":{"rendered":"Institute for Clinical Biochemistry and Pathobiochemistry"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row full_width=&#8221;stretch_row&#8221; full_height=&#8221;yes&#8221; columns_placement=&#8221;bottom&#8221; css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1583493907315{padding-top: 0px !important;padding-bottom: 0px !important;background-image: url(https:\/\/ddz.de\/wp-content\/uploads\/ikpb-hauptbild.jpg?id=19260) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}&#8221;][vc_column width=&#8221;1\/2&#8243; css=&#8221;.vc_custom_1558338474209{background-color: #ffffff !important;}&#8221; el_class=&#8221;meta-description-box&#8221;][vc_raw_html]JTVCZGR6aWNvbiU1RCUzQ3NwYW4lMjBjbGFzcyUzRCUyMm1ldGEtZGVzY3JpcHRpb24lMjIlM0UlNUJtZXRhX2Rlc2NyaXB0aW9uJTVEJTNDJTJGc3BhbiUzRQ==[\/vc_raw_html][\/vc_column][vc_column width=&#8221;1\/2&#8243;][\/vc_column][\/vc_row][vc_row el_class=&#8221;distance-top-small&#8221;][vc_column][vc_column_text]<\/p>\n<h2>The Institute for Clinical Biochemistry and Pathobiochemistry investigates the molecular basis of onset and progression of obesity, insulin resistance and type 2 diabetes. <span style=\"font-weight: 200;\">Our aim is to gain insights that may lead to improvements in prevention, prediction and therapy of diabetes.<\/span><\/h2>\n<p>&nbsp;<\/p>\n<p>Therefore, we pursue several research strategies:[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<ul>\n<li>Experimental mouse genetics allows the identification of yet unknown risk genes for obesity and diabetes (positional cloning) and constitutes a powerful tool to investigate complex gene\/gene and gene\/environment interactions in obesity and diabetes<\/li>\n<li>Physiological studies focus on interactions between different organs and cell types (crosstalk) and their role in the development of insulin resistance and type 2 diabetes. A particular emphasis is on the interaction between adipose tissue and muscle<\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li>Molecular and cell biology studies of cultured cells and tissues allow detailed investigation of relevant regulatory pathways and may provide functional evidence for an involvement of particular risk factors and their mechanism of action in the onset of obesity and diabetes<\/li>\n<li>High-throughput methods, such as mass spectroscopy-based proteome mapping, allow comprehensive investigation of complex regulatory networks and identification of novel predictive biomarkers for diabetes mellitus and secondary complications<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row el_class=\"distance-top\"][vc_column][vc_column_text]<\/p>\n<h2 style=\"text-align: center;\">Managing Directors<\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=\"1\/2\"][vc_raw_html]JTVCc3RhZmYlMjB1bml0X2lkJTNEJTIyNTk4MiUyMiUyMGdyb3VwJTNEJTIyZXhlY3V0aXZlcyUyMiUyMGNlbnRlciUzRCUyMnRydWUlMjIlMkYlNUQ=[\/vc_raw_html][\/vc_column][vc_column width=\"1\/2\"][vc_raw_html]JTVCc3RhZmYlMjB1bml0X2lkJTNEJTIyNTk4MiUyMiUyMGdyb3VwJTNEJTIyYXNzaXN0YW50cyUyMiUyMGNlbnRlciUzRCUyMnRydWUlMjIlMkYlNUQ=[\/vc_raw_html][\/vc_column][\/vc_row][vc_row][vc_column][vc_raw_html]JTVCcG9zdHMlNUQlMEElN0IlMEElMDklMjJ1aWQlMjIlM0ElMjJhZ3MlMjIlMkMlMEElMDklMjJ0aXRsZSUyMiUzQSUyMlJlc2VhcmNoJTIwR3JvdXBzJTIwJTI2JTIwUGxhdGZvcm1zJTIyJTJDJTBBJTA5JTIyb3V0cHV0VHlwZSUyMiUzQSUyMnN0YXRpYyUyMiUyQyUwQSUwOSUyMmFsaWdubWVudCUyMiUzQSUyMmNlbnRlciUyMiUyQyUwQSUwOSUyMmhpZGVDdXJyZW50SXRlbSUyMiUzQWZhbHNlJTJDJTBBJTA5JTIydGV4dElmRW1wdHklMjIlM0ElMjIlMjIlMkMlMEElMDklMjJjbGFzcyUyMiUzQSUyMmRpc3RhbmNlLXRvcCUyMiUyQyUwQSUwOSUyMnRhYnMlMjIlM0ElNUIlMEElMDklMDklN0IlMEElMDklMDklMDklMjJwb3N0VHlwZSUyMiUzQSUyMnBhZ2UlMjIlMkMlMEElMDklMDklMDklMjJjYXRlZ29yaWVzJTIyJTNBJTVCNzAlNUQlMkMlMEElMDklMDklMDklMjJ0YWJUaXRsZSUyMiUzQSUyMCUyMiUyMiUyQyUwQSUwOSUwOSUwOSUyMnRhYklkJTIyJTNBJTIwJTIyJTIyJTJDJTBBJTA5JTA5JTA5JTIyc29ydFR5cGUlMjIlM0ElMjJtZW51JTIyJTJDJTBBJTA5JTA5JTA5JTIyc29ydERpcmVjdGlvbiUyMiUzQSUyMmFzYyUyMiUyQyUwQSUwOSUwOSUwOSUyMmluY2x1ZGVTdWJjYXRzJTIyJTNBZmFsc2UlMkMlMEElMDklMDklMDklMjJpdGVtc1BlclBhZ2UlMjIlM0E5OTklMkMlMEElMDklMDklMDklMjJkaXNwbGF5VHlwZSUyMiUzQSUyMmJveCUyMiUyQyUwQSUwOSUwOSUwOSUyMnJlc3BvbnNpdmVDb2xzJTIyJTNBMyUyQyUwQSUwOSUwOSUwOSUyMnNob3dJbWFnZSUyMiUzQXRydWUlMkMlMEElMDklMDklMDklMjJzaG93VGl0bGUlMjIlM0F0cnVlJTJDJTBBJTA5JTA5JTA5JTIyc2hvd0RhdGUlMjIlM0FmYWxzZSUyQyUwQSUwOSUwOSUwOSUyMnRleHRQcmV2aWV3JTIyJTNBJTIybWV0YSUyMiUyQyUwQSUwOSUwOSUwOSUyMnRleHRQcmV2aWV3TGltaXQlMjIlM0EzMDAlMkMlMEElMDklMDklMDklMjJkZXNjcmlwdGlvbiUyMiUzQSUyMiUyMiUyQyUwQSUwOSUwOSUwOSUyMnRleHRJZkVtcHR5JTIyJTNBJTIyJTIyJTBBJTA5JTA5JTdEJTBBJTA5JTVEJTBBJTdEJTBBJTVCJTJGcG9zdHMlNUQ=[\/vc_raw_html][\/vc_column][\/vc_row][vc_row el_class=\"distance-top\"][vc_column][vc_tta_tour tab_position=\"right\" active_section=\"1\"][vc_tta_section i_icon_fontawesome=\"fa fa-graduation-cap\" add_icon=\"true\" title=\"Teaching Activities\" tab_id=\"1558092959705-8c4e50b8-b910\"][vc_column_text]<\/p>\n<h2>Teaching activities at Heinrich Heine University D\u00fcsseldorf<\/h2>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li>Interdisciplinary Research Training Group 2576 \u201cvivid - in vivo investigations towards the early development of type 2 diabetes\u201d<br \/>\n<a href=\"http:\/\/www.vivid.hhu.de\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/www.vivid.hhu.de<\/a><br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20042 \" style=\"display: inline-block; margin-top: 15px;\" src=\"https:\/\/ddz.de\/wp-content\/uploads\/vividLogo2020_RBG.png\" alt=\"vivid logo\" width=\"140\" height=\"40\" srcset=\"https:\/\/ddz.de\/wp-content\/uploads\/vividLogo2020_RBG.png 567w, https:\/\/ddz.de\/wp-content\/uploads\/vividLogo2020_RBG-300x86.png 300w\" sizes=\"auto, (max-width: 140px) 100vw, 140px\" \/><\/li>\n<li>Masters Study Programme Molecular Biomedicine<br \/>\n<a href=\"http:\/\/www.molekularebiomedizin.hhu.de\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/www.molekularebiomedizin.hhu.de<\/a><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section i_icon_fontawesome=\"fa fa-external-link-square\" add_icon=\"true\" title=\"Resources\" tab_id=\"1557389608704-4b383e9e-7c92\"][vc_column_text]<\/p>\n<h2>Resources<\/h2>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li>Interactive map of genetic loci for\u00a0<a class=\"link_std\" href=\"http:\/\/www.diabesitygenes.org\/\" target=\"_blank\" rel=\"noopener noreferrer\">diabetes mellitus<\/a>\u00a0und\u00a0<a class=\"link_std\" href=\"http:\/\/www.obesitygenes.org\/\" target=\"_blank\" rel=\"noopener noreferrer\">obesity<\/a>\u00a0in mice<\/li>\n<li><a class=\"link_std\" href=\"http:\/\/www.diabesityprot.org\/\" target=\"_blank\" rel=\"noopener noreferrer\">Diabetes proteome database<\/a><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][\/vc_tta_tour][\/vc_column][\/vc_row][vc_row][vc_column][vc_raw_html]JTVCcG9zdHMlNUQlMEElN0IlMEElMDklMjJ1aWQlMjIlM0ElMjJhZ3MlMjIlMkMlMEElMDklMjJ0aXRsZSUyMiUzQSUyMk90aGVyJTIwSW5zdGl0dXRlcyUyMGFuZCUyMFJlc2VhcmNoJTIwQXJlYXMlMjIlMkMlMEElMDklMjJvdXRwdXRUeXBlJTIyJTNBJTIyc3RhdGljJTIyJTJDJTBBJTA5JTIyYWxpZ25tZW50JTIyJTNBJTIyY2VudGVyJTIyJTJDJTBBJTA5JTIyaGlkZUN1cnJlbnRJdGVtJTIyJTNBdHJ1ZSUyQyUwQSUwOSUyMnRleHRJZkVtcHR5JTIyJTNBJTIyJTIyJTJDJTBBJTA5JTIyY2xhc3MlMjIlM0ElMjJzZXBhcmF0b3ItdG9wJTIyJTJDJTBBJTA5JTIydGFicyUyMiUzQSU1QiUwQSUwOSUwOSU3QiUwQSUwOSUwOSUwOSUyMnBvc3RUeXBlJTIyJTNBJTIycGFnZSUyMiUyQyUwQSUwOSUwOSUwOSUyMmNhdGVnb3JpZXMlMjIlM0ElNUI2OSU1RCUyQyUwQSUwOSUwOSUwOSUyMnRhYlRpdGxlJTIyJTNBJTIwJTIyJTIyJTJDJTBBJTA5JTA5JTA5JTIydGFiSWQlMjIlM0ElMjAlMjIlMjIlMkMlMEElMDklMDklMDklMjJzb3J0VHlwZSUyMiUzQSUyMm1lbnUlMjIlMkMlMEElMDklMDklMDklMjJzb3J0RGlyZWN0aW9uJTIyJTNBJTIyYXNjJTIyJTJDJTBBJTA5JTA5JTA5JTIyaW5jbHVkZVN1YmNhdHMlMjIlM0FmYWxzZSUyQyUwQSUwOSUwOSUwOSUyMml0ZW1zUGVyUGFnZSUyMiUzQTk5OSUyQyUwQSUwOSUwOSUwOSUyMmRpc3BsYXlUeXBlJTIyJTNBJTIybGlzdCUyMiUyQyUwQSUwOSUwOSUwOSUyMmhpZGVDdXJyZW50SXRlbSUyMiUzQXRydWUlMkMlMEElMDklMDklMDklMjJyZXNwb25zaXZlQ29scyUyMiUzQTElMkMlMEElMDklMDklMDklMjJzaG93SW1hZ2UlMjIlM0FmYWxzZSUyQyUwQSUwOSUwOSUwOSUyMnNob3dUaXRsZSUyMiUzQXRydWUlMkMlMEElMDklMDklMDklMjJzaG93RGF0ZSUyMiUzQWZhbHNlJTJDJTBBJTA5JTA5JTA5JTIydGV4dFByZXZpZXclMjIlM0ElMjJub25lJTIyJTJDJTBBJTA5JTA5JTA5JTIydGV4dFByZXZpZXdMaW1pdCUyMiUzQTMwMCUyQyUwQSUwOSUwOSUwOSUyMmRlc2NyaXB0aW9uJTIyJTNBJTIyJTIyJTJDJTBBJTA5JTA5JTA5JTIydGV4dElmRW1wdHklMjIlM0ElMjIlMjIlMEElMDklMDklN0QlMEElMDklNUQlMEElN0QlMEElNUIlMkZwb3N0cyU1RA==[\/vc_raw_html][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row full_width=&#8221;stretch_row&#8221; full_height=&#8221;yes&#8221; columns_placement=&#8221;bottom&#8221; css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1583493907315{padding-top: 0px !important;padding-bottom: 0px !important;background-image: url(https:\/\/ddz.de\/wp-content\/uploads\/ikpb-hauptbild.jpg?id=19260) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}&#8221;][vc_column width=&#8221;1\/2&#8243; css=&#8221;.vc_custom_1558338474209{background-color: #ffffff !important;}&#8221; el_class=&#8221;meta-description-box&#8221;][vc_raw_html]JTVCZGR6aWNvbiU1RCUzQ3NwYW4lMjBjbGFzcyUzRCUyMm1ldGEtZGVzY3JpcHRpb24lMjIlM0UlNUJtZXRhX2Rlc2NyaXB0aW9uJTVEJTNDJTJGc3BhbiUzRQ==[\/vc_raw_html][\/vc_column][vc_column width=&#8221;1\/2&#8243;][\/vc_column][\/vc_row][vc_row el_class=&#8221;distance-top-small&#8221;][vc_column][vc_column_text] The investigates the molecular basis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":19260,"parent":17711,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[192],"tags":[],"class_list":["post-18121","page","type-page","status-publish","has-post-thumbnail","hentry","category-research"],"acf":{"ddz-icon":"https:\/\/ddz.de\/wp-content\/uploads\/icon-ikbp-1.png","attachments":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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