{"id":18091,"date":"2019-10-29T19:31:52","date_gmt":"2019-10-29T18:31:52","guid":{"rendered":"https:\/\/2020.ddz.de\/?page_id=18091"},"modified":"2020-10-12T08:11:24","modified_gmt":"2020-10-12T07:11:24","slug":"research-group-energy-metabolism","status":"publish","type":"page","link":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/","title":{"rendered":"Research Group Energy Metabolism"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_single_image source=&#8221;featured_image&#8221; img_size=&#8221;full&#8221;][vc_column_text]<\/p>\n<h2>The research group studies metabolic pathways and their regulation in various human tissues and organs.<\/h2>\n<p>The main focus is the identification and characterization of acquired and (epi)genetic triggers of insulin resistance, diabetes mellitus and non-alcoholic fatty liver disease (NAFLD). Specific attention lies on the role of mitochondria (the cell\u00b4s \u201cpower plants\u201d) for energy metabolism.<\/p>\n<p>The aims are to gain insight into the key abnormalities of energy metabolism, which contribute to the development of metabolic diseases and allow for identifying novel options for the prevention and therapy of diabetes and its comorbidities and complications.<\/p>\n<h2>Aims<\/h2>\n<ul>\n<li>Characterizing metabolic flux rates and the mitochondrial function in skeletal muscle, liver and adipose tissue in healthy humans and those with metabolic diseases<\/li>\n<li>Investigation of the role of NAFLD in the development and progression of insulin resistance and the metabolic syndrome<\/li>\n<li>Testing the effects of exercise training, diet and medication on tissue-specific insulin action and molecular mechanisms of its regulation<\/li>\n<li>Development of innovative methods for non-invasive examination of energy metabolism<\/li>\n<\/ul>\n<p>The research group has made contributions to understanding of glucose transport\/phosphorylation, glycogen synthesis\/-lysis and gluconeogenesis in healthy individuals and humans with diabetes mellitus. The group described the cellular mechanisms of fatty acid- and amino acid-induced insulin resistance. A concept for the adaptation of mitochondrial function in the liver of obese persons was developed. Multicenter studies demonstrated the effects of differently composed nutritional lipids and blood-glucose lowering therapies for the improvement of insulin resistance and reduction of liver fat in people with type 2 diabetes.<\/p>\n<p>The research group established and is developing - in collaboration with the research group Metabolic Imaging of the institute - methods using stable isotope dilution and non-invasive magnetic resonance spectroscopy to examine the fat content of different organs, concentrations of metabolites, flux rates through metabolic pathways and energy production (ATP synthesis) in human liver, muscle and brain.[\/vc_column_text][vc_btn title=\"Rodenlab Website\" link=\"url:https%3A%2F%2Frodenlab.de%2F||target:%20_blank|\"][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row el_class=\"distance-top-small\"][vc_column][vc_tta_tour tab_position=\"right\" active_section=\"1\"][vc_tta_section i_icon_fontawesome=\"fa fa-users\" add_icon=\"true\" title=\"Team\" tab_id=\"1557219375391-43fad21d-8602\"][vc_column_text]<\/p>\n<h2>Team<\/h2>\n<p>[\/vc_column_text][vc_column_text]<div class=\" pure-data shortcodes color-links\"><div class=\"visitenkarten-container\"><div class=\"visitenkarte\">\r\n\t\t\t\t\t<div class=\"inner\">\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"portrait\" style=\"background-image:url(https:\/\/api.ddz.de\/file\/get\/d3452bf7dcb57d1cd53443d0ea3b86ec837eae2eb9b5c9011c83e16210c28396.jpg)\" title=\"Portrait image of Univ.-Prof. Dr. Michael Roden\"><\/div>\r\n\t\t\t\t\t\t\r\n\r\n\t\t\t\t\t\t<div class=\"left\">\r\n\t\t\t\t\t\t\t<div class=\"name mb-3\">Univ.-Prof. Dr. Michael Roden<\/div>\r\n\t\t\t\t\t\t\t<div class=\"units-roles mt-2 clear-first\"><div class=\"roles-and-unit mt-2 clear-first\"><div class=\"roles hyphens\"><span class=\"role hyphens mb-1 clear-last\">Head<\/span><\/div><div class=\"orgaunit hyphens\">Research Group Energy Metabolism<\/div><\/div><\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t<div class=\"contacts mt-4\">\r\n\t\t\t\t\t\t\t\t<div class=\"email mt-2\"><a href=\"mailto:beate.stodieck@ddz.de\" title=\"Send e-mail to Univ.-Prof. Dr. Michael Roden\"><i class=\"fa fa-envelope\"><\/i> beate.stodieck@ddz.de<\/a><\/div>\r\n\t\t\t\t\t\t\t\t<div class=\"phones mt-2\"><div class=\"phone mt-1 clear-first\"><i class=\"fa fa-phone\"><\/i>+49 211 3382-201<\/div><\/div>\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t<div class=\"author-link mt-4\"><a href=\"\/author\/?id=6899#univ-prof-dr-michael-roden\" title=\"View selected publications of Univ.-Prof. Dr. Michael Roden\"><i class=\"fa fa-user\"><\/i>Selected publications<\/a><\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div><\/div><div class=\"persons-container\"><ul class=\"special table tr-pad td-pad-l tr-sep td-sep\"><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Viyan Batal<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:viyan.batal@ddz.de\" title=\"E-Mail senden an Viyan Batal\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Dr. Bedair Dewidar<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:bedair.dewidar@ddz.de\" title=\"E-Mail senden an Dr. Bedair Dewidar\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Olga D\u00fcrrschmidt<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:olga.duerrschmidt@ddz.de\" title=\"E-Mail senden an Olga D\u00fcrrschmidt\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Roopali Melanie Einw\u00e4chter<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:roopali.einwaechter@ddz.de\" title=\"E-Mail senden an Roopali Melanie Einw\u00e4chter\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Laura Gimeno Tello<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Mona Hendlinger , M. Sc.<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:mona.hendlinger@ddz.de\" title=\"E-Mail senden an Mona Hendlinger , M. Sc.\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Maximilian Huttasch<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:maximilian.huttasch@ddz.de\" title=\"E-Mail senden an Maximilian Huttasch\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Friedrich Jassil, Dr.<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:friedrich.jassil@ddz.de\" title=\"E-Mail senden an Friedrich Jassil, Dr.\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Dr. med. Sabine Kahl<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:sabine.kahl@ddz.de\" title=\"E-Mail senden an Dr. med. Sabine Kahl\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Katerina Koudelkova<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:katerina.koudelkova@ddz.de\" title=\"E-Mail senden an Katerina Koudelkova\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Jan-Marc Leonhard, B. Sc.<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:jan-marc.leonhard@ddz.de\" title=\"E-Mail senden an Jan-Marc Leonhard, B. Sc.\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Dr. rer. nat. Lucia Mastrototaro<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:lucia.mastrototaro@ddz.de\" title=\"E-Mail senden an Dr. rer. nat. Lucia Mastrototaro\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Dr. med. Aika Miya, MD<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:aika.miya@ddz.de\" title=\"E-Mail senden an Dr. med. Aika Miya, MD\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Jessica Oberh\u00e4user<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:jessica.oberhaeuser@ddz.de\" title=\"E-Mail senden an Jessica Oberh\u00e4user\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Sarah Piel<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Michelle Reina do Fundo<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:michelle.reinadofundo@ddz.de\" title=\"E-Mail senden an Michelle Reina do Fundo\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Thamara Rodrigues Bazilio<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Merve Sahin<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:merve.sahin@ddz.de\" title=\"E-Mail senden an Merve Sahin\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Prof. Dr. Patrick Schrauwen<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:patrick.schrauwen@ddz.de\" title=\"E-Mail senden an Prof. Dr. Patrick Schrauwen\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Anita Shokouhmehr, M. Sc.<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:anita.shokouhmehr@ddz.de\" title=\"E-Mail senden an Anita Shokouhmehr, M. Sc.\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Paula Sonntag<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Alexandra Stein<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:alexandra.stein@ddz.de\" title=\"E-Mail senden an Alexandra Stein\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Dr. rer. med. Nina Trinks<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:nina.trinks@ddz.de\" title=\"E-Mail senden an Dr. rer. med. Nina Trinks\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Merle Wolke<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Georgia Xourafa<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:georgia.xourafa@ddz.de\" title=\"E-Mail senden an Georgia Xourafa\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Dr. Sevgican  Yilmaz<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:sevgican.yilmaz@ddz.de\" title=\"E-Mail senden an Dr. Sevgican  Yilmaz\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Fariba Zivehe<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:fariba.zivehe@ddz.de\" title=\"E-Mail senden an Fariba Zivehe\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><li class=\"tr pad sep\">\r\n\t\t\t\t\t<div class=\"td\">\r\n\t\t\t\t\t\t<span class=\"name\">Claudia Zundel, Dipl. Biol.<\/span>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"td\"><a href=\"mailto:claudia.zundel@ddz.de\" title=\"E-Mail senden an Claudia Zundel, Dipl. Biol.\"><i class=\"fa fa-envelope\"><\/i><\/a><\/div>\r\n\t\t\t\t<\/li><\/ul><\/div><\/div>[\/vc_column_text][\/vc_tta_section][vc_tta_section i_icon_fontawesome=\"fa fa-leanpub\" add_icon=\"true\" title=\"Selected Publications\" tab_id=\"1557219386270-21db6446-ffce\"][vc_column_text]<\/p>\n<h2>Selected Publications<\/h2>\n<p>[\/vc_column_text][vc_column_text]<div class=\" pure-data shortcodes color-links\"><ul class=\"publications special color-links\"><li>Gancheva S, Ouni M, Jelenik T, Koliaki C, Szendroedi J, Toledo FGS, Markgraf DF, Pesta DH, Mastrototaro L, De Filippo E, Herder C, J\u00e4hnert M, Weiss J, Strassburger K, Schlensak M, Sch\u00fcrmann A, Roden M 2019. <span class=\"title\" lang=\"en\">Dynamic changes of muscle insulin sensitivity after metabolic surgery.<\/span> Nat Commun. 10. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41467-019-12081-0\" title=\"Open the website of the publication &#187;Dynamic changes of muscle insulin sensitivity after metabolic surgery&#171;\">https:\/\/doi.org\/10.1038\/s41467-019-12081-0<\/a><\/li><li>Roden M, Shulman GI 2019. <span class=\"title\" lang=\"en\">The integrative biology of type 2 diabetes.<\/span> Nature. 576: 51-60. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41586-019-1797-8\" title=\"Open the website of the publication &#187;The integrative biology of type 2 diabetes&#171;\">https:\/\/doi.org\/10.1038\/s41586-019-1797-8<\/a><\/li><li>Gancheva S, Jelenik T, \u00c1lvarez-Hern\u00e1ndez E, Roden M 2018. <span class=\"title\" lang=\"en\">Interorgan Metabolic Crosstalk in Human Insulin Resistance.<\/span> Physiol Rev. 98: 1371-1415. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1152\/physrev.00015.2017\" title=\"Open the website of the publication &#187;Interorgan Metabolic Crosstalk in Human Insulin Resistance&#171;\">https:\/\/doi.org\/10.1152\/physrev.00015.2017<\/a><\/li><li>Apostolopoulou M, Gordillo R, Koliaki C, Gancheva S, Jelenik T, De Filippo E, Herder C, Markgraf D, Jankowiak F, Esposito I, Schlensak M, Scherer PE, Roden M 2018. <span class=\"title\" lang=\"en\">Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis.<\/span> Diabetes Care. 41: 1235-1243. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.2337\/dc17-1318\" title=\"Open the website of the publication &#187;Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis&#171;\">https:\/\/doi.org\/10.2337\/dc17-1318<\/a><\/li><li>\u00c1lvarez-Hern\u00e1ndez E, Kahl S, Seelig A, Begovatz P, Irmler M, Kupriyanova Y, Nowotny B, Nowotny P, Herder C, Barosa C, Carvalho F, Rozman J, Neschen S, Jones JG, Beckers J, de Angelis MH, Roden M 2017. <span class=\"title\" lang=\"en\">Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance.<\/span> J Clin Invest. 127: 695-708. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1172\/JCI89444\" title=\"Open the website of the publication &#187;Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance&#171;\">https:\/\/doi.org\/10.1172\/JCI89444<\/a><\/li><li>Gancheva S, Koliaki C, Bierwagen A, Nowotny P, Heni M, Fritsche A, H\u00e4ring H-U, Szendroedi J, Roden M 2015. <span class=\"title\" lang=\"en\">Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans.<\/span> Diabetes. 64: 1966-75. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.2337\/db14-0892\" title=\"Open the website of the publication &#187;Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans&#171;\">https:\/\/doi.org\/10.2337\/db14-0892<\/a><\/li><li>Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, Schlensak M, Roden M 2015. <span class=\"title\" lang=\"en\">Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis.<\/span> Cell Metab. 21: 739-46. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.cmet.2015.04.004\" title=\"Open the website of the publication &#187;Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis&#171;\">https:\/\/doi.org\/10.1016\/j.cmet.2015.04.004<\/a><\/li><li>Szendroedi J, Yoshimura T, Phielix E, Koliaki C, Marcucci M, Zhang D, Jelenik T, M\u00fcller J, Herder C, Nowotny P, Shulman GI, Roden M 2014. <span class=\"title\" lang=\"en\">Role of diacylglycerol activation of PKC\u03b8 in lipid-induced muscle insulin resistance in humans.<\/span> P Natl Acad Sci U S A. 111: 9597-602. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1073\/pnas.1409229111\" title=\"Open the website of the publication &#187;Role of diacylglycerol activation of PKC\u03b8 in lipid-induced muscle insulin resistance in humans&#171;\">https:\/\/doi.org\/10.1073\/pnas.1409229111<\/a><\/li><li>Roden M, Price T, Perseghin G, Petersen K, Rothman D, Cline GW, Shulman GI 1996. <span class=\"title\" lang=\"en\">Mechanism of free fatty acid-induced insulin resistance in humans.<\/span> J Clin Invest. 97: 2859-2865. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1172\/JCI118742\" title=\"Open the website of the publication &#187;Mechanism of free fatty acid-induced insulin resistance in humans&#171;\">https:\/\/doi.org\/10.1172\/JCI118742<\/a><\/li><li><span class=\"title\" lang=\"en\">.<\/span><\/li><\/ul><\/div>[\/vc_column_text][\/vc_tta_section][vc_tta_section i_icon_fontawesome=\"fa fa-handshake-o\" add_icon=\"true\" title=\"Cooperations\" tab_id=\"1557308494754-f9a09df0-a4cc\"][vc_column_text]<\/p>\n<h2>National Cooperations<\/h2>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li>Partners and associated Partners of the German Center for Diabetes Research (DZD e. V.): All Partners<\/li>\n<li>Sch\u00f6n Klinik, D\u00fcsseldorf: Dr. Matthias Schlensak<\/li>\n<li>Florence Nightingale KH, Kaiserswerth: PD Dr. Matthias Banasch<\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<h2>International Cooperations<\/h2>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li>Yale Universit\u00e4t, New Haven, Connecticut, USA: Prof. Gerald I. Shulman<\/li>\n<li>Universit\u00e4t Coimbra, Coimbra, Portugal: Prof. John G. Jones<\/li>\n<li>Universit\u00e4t Texas, Southwestern Medical Center, Dallas, Texas, USA: Prof. Phil Scherer<\/li>\n<li>Universit\u00e4t Maastricht, Maastricht, Niederlande: Prof. Patrick Schrauwen<\/li>\n<li>Universit\u00e4t Lund, Lund, Schweden: Prof. Leif Groop<\/li>\n<li>Universit\u00e4t Padova, Padova, Italien: Prof. Giovanni Pacini and Andrea Tura<\/li>\n<li>Universit\u00e4t Pisa, Pisa, Italien: Prof. Amalia Gastaldelli<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section i_icon_fontawesome=\"fa fa-rocket\" add_icon=\"true\" title=\"Competitive third-party funds\" tab_id=\"1581927029962-d03aa281-4c8c\"][vc_column_text]<\/p>\n<h2>Competitive third-party funds<\/h2>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li>European Commission (EUREKA Eurostars-2 E!, 113230)<\/li>\n<li>Deutsche Forschungsgemeinschaft: (DFG: CRC\/SFB 1116\/2 B12, GRK 2576 P3)<\/li>\n<li>Deutsche Diabetes Gesellschaft (DDG)<\/li>\n<li>Ministerium f\u00fcr Kultur und Wissenschaft (MKW: EFRE-0400191)<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section i_icon_fontawesome=\"fa fa-graduation-cap\" add_icon=\"true\" title=\"Teaching Activities\" tab_id=\"1581927428527-5e38f825-6b19\"][vc_column_text]<\/p>\n<h2>Teaching Activities at Heinrich Heine University D\u00fcsseldorf<\/h2>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li>Diabetologisch-metabolisches Seminar (Prof. Roden)<\/li>\n<li>Klinisch-experimentelle Diabetologie (Prof. Roden)<\/li>\n<li>Endokrine Stoffwechselregulation: From bed to bench and back! (Prof. Roden)<\/li>\n<li>Experimentelle Methoden in der Diabetesforschung (Prof. Roden)<\/li>\n<li>Hot topics in molecular exercise science &amp; endocrinology (Dr. Pesta)<\/li>\n<li>Wahlfach Immunbiologie (Dr. Pesta\/Dr. Kahl\/Dr. Mastrototaro\/Dr. Sarabhai)<\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<h2>Teaching Activities at other national\/international Universities<\/h2>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li>Glucotoxicity, lipotoxicity, mitochondrial oxidative stress, MSc Program \"Diabetes Mellitus and Obesity\", Universit\u00e4t Athen (Prof. Roden)<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][\/vc_tta_tour][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_single_image source=&#8221;featured_image&#8221; img_size=&#8221;full&#8221;][vc_column_text] The main focus is the identification and characterization of acquired and (epi)genetic triggers of insulin resistance, diabetes mellitus and non-alcoholic fatty liver disease (NAFLD). Specific attention lies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":19091,"parent":17754,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[193],"tags":[],"class_list":["post-18091","page","type-page","status-publish","has-post-thumbnail","hentry","category-institute-for-clinical-diabetologie"],"acf":{"ddz-icon":false,"attachments":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research Group Energy Metabolism - Deutsches Diabetes-Zentrum (DDZ)<\/title>\n<meta name=\"description\" content=\"The research group studies metabolic pathways and their regulation in various human tissues and organs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[unit_name foo=&quot;Research Group Energy Metabolism&quot; unit_id=&quot;6087&quot;\/] - Deutsches Diabetes-Zentrum (DDZ)\" \/>\n<meta property=\"og:description\" content=\"The research group studies metabolic pathways and their regulation in various human tissues and organs.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/\" \/>\n<meta property=\"og:site_name\" content=\"Deutsches Diabetes-Zentrum (DDZ)\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/diabetesinformationsdienst\/\" \/>\n<meta property=\"article:modified_time\" content=\"2020-10-12T07:11:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ddz.de\/wp-content\/uploads\/ag-energie2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"667\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@ddz_info\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/\",\"url\":\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/\",\"name\":\"[unit_name foo=\\\"Research Group Energy Metabolism\\\" unit_id=\\\"6087\\\"\/] - Deutsches Diabetes-Zentrum (DDZ)\",\"isPartOf\":{\"@id\":\"https:\/\/ddz.de\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ddz.de\/wp-content\/uploads\/ag-energie2.jpg\",\"datePublished\":\"2019-10-29T18:31:52+00:00\",\"dateModified\":\"2020-10-12T07:11:24+00:00\",\"description\":\"The research group studies metabolic pathways and their regulation in various human tissues and organs.\",\"breadcrumb\":{\"@id\":\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/#primaryimage\",\"url\":\"https:\/\/ddz.de\/wp-content\/uploads\/ag-energie2.jpg\",\"contentUrl\":\"https:\/\/ddz.de\/wp-content\/uploads\/ag-energie2.jpg\",\"width\":1000,\"height\":667,\"caption\":\"Oxygraph wird im Labor der AG Energiestoffwechsel verwendet\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\/\/ddz.de\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\/\/ddz.de\/en\/research\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Institut f\u00fcr Klinische Diabetologie\",\"item\":\"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Research Group Energy Metabolism\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/ddz.de\/en\/#website\",\"url\":\"https:\/\/ddz.de\/en\/\",\"name\":\"Deutsches Diabetes-Zentrum (DDZ)\",\"description\":\"Diabetes erforschen - Menschen helfen\",\"publisher\":{\"@id\":\"https:\/\/ddz.de\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/ddz.de\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/ddz.de\/en\/#organization\",\"name\":\"Deutsches Diabetes-Zentrum (DDZ)\",\"url\":\"https:\/\/ddz.de\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ddz.de\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/ddz.de\/wp-content\/uploads\/ddz_logo_de.png\",\"contentUrl\":\"https:\/\/ddz.de\/wp-content\/uploads\/ddz_logo_de.png\",\"width\":640,\"height\":226,\"caption\":\"Deutsches Diabetes-Zentrum (DDZ)\"},\"image\":{\"@id\":\"https:\/\/ddz.de\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/diabetesinformationsdienst\/\",\"https:\/\/x.com\/ddz_info\",\"https:\/\/www.youtube.com\/channel\/UCNxwshEljrBJXPri-w9IiLg\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Research Group Energy Metabolism - Deutsches Diabetes-Zentrum (DDZ)","description":"The research group studies metabolic pathways and their regulation in various human tissues and organs.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/","og_locale":"en_US","og_type":"article","og_title":"[unit_name foo=\"Research Group Energy Metabolism\" unit_id=\"6087\"\/] - Deutsches Diabetes-Zentrum (DDZ)","og_description":"The research group studies metabolic pathways and their regulation in various human tissues and organs.","og_url":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/","og_site_name":"Deutsches Diabetes-Zentrum (DDZ)","article_publisher":"https:\/\/www.facebook.com\/diabetesinformationsdienst\/","article_modified_time":"2020-10-12T07:11:24+00:00","og_image":[{"width":1000,"height":667,"url":"https:\/\/ddz.de\/wp-content\/uploads\/ag-energie2.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_site":"@ddz_info","twitter_misc":{"Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/","url":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/","name":"[unit_name foo=\"Research Group Energy Metabolism\" unit_id=\"6087\"\/] - Deutsches Diabetes-Zentrum (DDZ)","isPartOf":{"@id":"https:\/\/ddz.de\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/#primaryimage"},"image":{"@id":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/#primaryimage"},"thumbnailUrl":"https:\/\/ddz.de\/wp-content\/uploads\/ag-energie2.jpg","datePublished":"2019-10-29T18:31:52+00:00","dateModified":"2020-10-12T07:11:24+00:00","description":"The research group studies metabolic pathways and their regulation in various human tissues and organs.","breadcrumb":{"@id":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/#primaryimage","url":"https:\/\/ddz.de\/wp-content\/uploads\/ag-energie2.jpg","contentUrl":"https:\/\/ddz.de\/wp-content\/uploads\/ag-energie2.jpg","width":1000,"height":667,"caption":"Oxygraph wird im Labor der AG Energiestoffwechsel verwendet"},{"@type":"BreadcrumbList","@id":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/research-group-energy-metabolism\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Startseite","item":"https:\/\/ddz.de\/en\/"},{"@type":"ListItem","position":2,"name":"Research","item":"https:\/\/ddz.de\/en\/research\/"},{"@type":"ListItem","position":3,"name":"Institut f\u00fcr Klinische Diabetologie","item":"https:\/\/ddz.de\/en\/research\/institute-for-clinical-diabetology\/"},{"@type":"ListItem","position":4,"name":"Research Group Energy Metabolism"}]},{"@type":"WebSite","@id":"https:\/\/ddz.de\/en\/#website","url":"https:\/\/ddz.de\/en\/","name":"Deutsches Diabetes-Zentrum (DDZ)","description":"Diabetes erforschen - Menschen helfen","publisher":{"@id":"https:\/\/ddz.de\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ddz.de\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/ddz.de\/en\/#organization","name":"Deutsches Diabetes-Zentrum (DDZ)","url":"https:\/\/ddz.de\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/ddz.de\/en\/#\/schema\/logo\/image\/","url":"https:\/\/ddz.de\/wp-content\/uploads\/ddz_logo_de.png","contentUrl":"https:\/\/ddz.de\/wp-content\/uploads\/ddz_logo_de.png","width":640,"height":226,"caption":"Deutsches Diabetes-Zentrum (DDZ)"},"image":{"@id":"https:\/\/ddz.de\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/diabetesinformationsdienst\/","https:\/\/x.com\/ddz_info","https:\/\/www.youtube.com\/channel\/UCNxwshEljrBJXPri-w9IiLg"]}]}},"_links":{"self":[{"href":"https:\/\/ddz.de\/en\/wp-json\/wp\/v2\/pages\/18091","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ddz.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ddz.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ddz.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ddz.de\/en\/wp-json\/wp\/v2\/comments?post=18091"}],"version-history":[{"count":24,"href":"https:\/\/ddz.de\/en\/wp-json\/wp\/v2\/pages\/18091\/revisions"}],"predecessor-version":[{"id":20963,"href":"https:\/\/ddz.de\/en\/wp-json\/wp\/v2\/pages\/18091\/revisions\/20963"}],"up":[{"embeddable":true,"href":"https:\/\/ddz.de\/en\/wp-json\/wp\/v2\/pages\/17754"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ddz.de\/en\/wp-json\/wp\/v2\/media\/19091"}],"wp:attachment":[{"href":"https:\/\/ddz.de\/en\/wp-json\/wp\/v2\/media?parent=18091"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ddz.de\/en\/wp-json\/wp\/v2\/categories?post=18091"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ddz.de\/en\/wp-json\/wp\/v2\/tags?post=18091"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}