Website (Home) of the German Diabetes Center Website of the Heinrich-Heine-University Düsseldorf Website of the Leibniz-Gemeinschaft e. V.
German Diabetes Center (DDZ)
Leibniz-Center for Diabetes-Research
at the Heinrich-Heine-University Düsseldorf
Auf'm Hennekamp 65, 40225 Düsseldorf
Phone: +49 (0)211 3382-0
Fax: +49 (0)211 3382-603
E-Mail: kontakt@ddz.uni-duesseldorf.de
Internet: http://ddz.uni-duesseldorf.de

Clinical Research Center (CRC)

Infos

The research group "Clinical Study Center" focuses on the analysis of diabetes in men with clinical and experimental methods.

Main research activities are

  • the detailed clinical, metabolic and immunologic characterisation of individuals with diabetes in observational studies like the German Diabetes Center (GDC) Study
  • the analysis of the underlying mechanisms in the development of insulin resistance and type 2 diabetes
  • the modification of the disease course of both type 1 and type 2 diabetes and its complications by pharmacological and lifestyle interventions.

Previous studies analysed whether the disease course of patients with type 1 or type 2 diabetes can be influenced by immune interventions, lifestyle changes and pharmacological interventions (phase I - IV studies). Besides regular clinical examinations (anthropometry, laboratory analysis and physical examination), numerous specialised analysis methods are available, such as Clamp-studies, ivGTT, endothelial function (FMD) and Intima-Media-Thickness (IMT), indirect calorimetry, spiroergometry, immunological characterization as well as biopsies and microdialysis of subcutaneous adipose tissue.

Research aims:

  • What are the mechanisms in the development of diabetes and its complications and what ist he impact of metabolic, immunologic and diet-related factors?
  • The the disease course and the development of complications modifiable by interventions and are the effective and long-lasting?


Messung der endothelabhängigen Vasodilatation
Analysis of endothelium-dependent vasodilatation (FMD) and one positive control to assess vessel functioning. By the calculation of vessel dilatation (FMD) in per cent an impairments of endothelial function can be analysed, which is regarded as one of the first steps in the development of atherosclerosis.

Group Members

Szendrödi, Julia, PD Dr. med.

Head
Clinical Research Center (CRC)

Tel.: +49-(0)-211-33-82-203

Müssig, Karsten, Prof. Dr. med.

Deputy Head
Clinical Research Center (CRC)

Tel.: +49-(0)-211-33-82-218

Fax: +49-(0)-211-33-82-609

Burkart, Volker, PD Dr. rer. nat.

Tel.: +49-(0)-211-33-82-641/656

Bódis, Kálmán

Tel.: +49-(0)-211-33-82-575

Domass, Petra

Tel.: +49-(0)-211-33-82-308

Heidkamp, Petra

Tel.: +49-(0)-211-33-82-209

Heitkamp, Gunhild, Dipl.-Ökotroph.

Tel.: +49-(0)-211-33-82-294

Karusheva, Yanislava

Tel.: +49-(0)-211-33-82-773

Kersting, Larissa

Klein-Piklaps, Viola

Tel.: +49-(0)-211-33-82-311

Kössler, Theresa

Tel.: +49-(0)-211-33-82-264

Möser, Clara
Gastmitarbeiterin

Tel.: +49-(0)-211-33-82-318

Parnian, Firouzi

Tel.: +49-(0)-211-33-82-319

Schindler, Anna-Luisa

Schulte, Monika

Tel.: +49-(0)-211-33-82-215

Sutkowski, Agnieszka

Tel.: +49-(0)-211-33-82-732

Tosenovian, Silke

Tel.: +49-(0)-211-33-82-596

Wallrafen, Patricia

Wischeidt, Robert

Tel.: +49-(0)-211-33-82-656

Zaharia, Oana-Patricia

Tel.: +49-(0)-211-33-82-795

Zweck, Elric
Gastmitarbeiter

Publications

Publications

2007 May
Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission.
Schloot NC, Hanifi-Moghaddam P, Aabenhus-Andersen N, Alizadeh BZ, Saha MT, Knip M, Devendra D, Wilkin T, Bonifacio E, Roep BO, Kolb H, Mandrup-Poulsen T
2007 May
Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials.
Schloot NC, Meierhoff G, Lengyel C, Vándorfi G, Takács J, Pánczél P, Barkai L, Madácsy L, Oroszlán T, Kovács P, Sütö G, Battelino T, Hosszufalusi N, Jermendy G
2008 Apr
Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes.
Pfleger C, Mortensen HB, Hansen L, Herder C, Roep BO, Hoey H, Aanstoot HJ, Kocova M, Schloot NC, Hvidøre Study Group on Childhood Diabetes
2008 Nov
In situ profiling of adipokines in subcutaneous microdialysates from lean and obese individuals.
Murdolo G, Herder C, Wang Z, Rose B, Schmelz M, Jansson PA
2008 Nov
Beneficial effects of external muscle stimulation on glycaemic control in patients with type 2 diabetes.
Rose B, Lankisch M, Herder C, Röhrig K, Kempf K, Labrenz S, Hänsler J, Koenig W, Heinemann L, Martin S
2008 Jul
Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes.
Pfleger C, Kaas A, Hansen L, Alizadeh B, Hougaard P, Holl R, Kolb H, Roep BO, Mortensen HB, Schloot NC, Hvidøre Study Group On Childhood Diabetes
2006 Feb
High prevalence of undiagnosed impaired glucose regulation and diabetes mellitus in patients scheduled for an elective coronary angiography.
Lankisch M, Füth R, Schotes D, Rose B, Lapp H, Rathmann W, Haastert B, Gülker H, Scherbaum WA, Martin S

Cooperations

External collaborators (alphabetical order)

  • Forschungsinstitut der Diabetes Akademie Mergentheim (FIDAM): B. Kulzer, N. Hermanns
  • Heinrich-Heine-Universität Düsseldorf, Institut für Pharmakologie und Klinische Phahrmakologie: T. Hohlfeld
  • Universität Giessen, Klinik für Psychosomatische Medizin und Psychotherapie: J. Kruse
  • Heinrich-Heine-Universität Düsseldorf, Klinik für Allgemeine Pädiatrie: T. Meissner, E. Mayatepek
  • Koordinierungszentrum für Klinische Studien, Heinrich-Heine Universität Düsseldorf: C. Ohmann

Grant Support

Grant support

  • BMBF
  • EU
  • Industriemittel (u.a. Takeda Pharma, MDS Services, Pfizer)
  • DZD
  • EFSD

Teaching Activities

Teaching activities at Heinrich-Heine University Düsseldorf

  • Doktorandenkolloquium diabetologisch-metabolisches Seminar (Nowotny)



Support Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen Bundesministerium für Gesundheit

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