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German Diabetes Center (DDZ)
Leibniz-Center for Diabetes-Research
at the Heinrich-Heine-University Düsseldorf
Auf'm Hennekamp 65, 40225 Düsseldorf
Phone: +49 (0)211 3382-0
Fax: +49 (0)211 3382-603
E-Mail: kontakt@ddz.uni-duesseldorf.de
Internet: http://ddz.uni-duesseldorf.de

Institute for Vascular and Islet Cell Biology

Infos

Our group investigates the pathomechanisms in pancreatic beta cells and endothelial cells in type 2 diabetes mellitus. The underlying hypothesis is that blood vascular changes support the development of type 2 diabetes. This hypothesis is consistent with the finding that many type 2 diabetes associated genes have a cardiovascular function. Moreover, mice with vascular defects in pancreatic islets are glucose intolerant and lack first phase insulin secretion. Therefore, the phenotype of these mice resembles the phenotype of early type 2 diabetic patients. To analyze blood vessels and vascular changes systematically, an imaging platform has been developed to qualitatively and quantitatively analyze blood vessels in tissues in vivo and in a 96-well screenable format in vitro. The platform is based on state-of-the-art fluorescence and laser scanning microscopes in combination with image analyses programs.

Moreover we analyze changes in mitochondria of pancreatic beta cells in diabetic and pre-diabetic mice. The underlying hypothesis is that the beta cells, besides the cells of peripheral tissues, harbor mitochondrial defects during type 2 diabetes. The molecular pathomechanisms in mitochondria are analyzed during development of type 2 diabetes and glucose intolerance in mice.

Our projects are

  • Analysis and pharmacological manipulation of blood vessels in 96-well assays
  • Analysis of blood vessels in mouse pancreatic islets
  • Analysis of pancreatic islets with mitochondrial defects in type 2 diabetic or glucose intolerant mice

Group Members

Lammert, Eckhard, Prof. Dr. rer. nat.

Director
Institute for Vascular and Islet Cell Biology

Fax: (0211) 81-13897

Belgardt, Bengt-Frederik, Dr. rer. nat.

Deputy Director
Institute for Vascular and Islet Cell Biology

Tel.: +49-(0)-211-33-82-451

Publications

Selected Publications

2013 Jun
Pharmacological inhibition of Eph receptors enhances glucose-stimulated insulin secretion from mouse and human pancreatic islets.
Jain R, Jain D, Liu Q, Bartosinska B, Wang J, Schumann D, Kauschke SG, Eickelmann P, Piemonti L, Gray NS, Lammert E
2013 Jan
Association of exercise-induced hyperinsulinaemic hypoglycaemia with MCT1-expressing insulinoma.
Marquard J, Welters A, Buschmann T, Barthlen W, Vogelgesang S, Klee D, Krausch M, Raffel A, Otter S, Piemonti L, Mayatepek E, Otonkoski T, Lammert E, Meissner T
2012 Nov
Pharmacological manipulation of blood and lymphatic vascularization in ex vivo-cultured mouse embryos.
Zeeb M, Axnick J, Planas-Paz L, Hartmann T, Strilic B, Lammert E
2012 Jul
Calcineurin/NFATc signaling: role in postnatal β cell development and diabetes mellitus.
Kragl M, Lammert E
2012 Aug
Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes.
Jain D, Jain R, Eberhard D, Eglinger J, Bugliani M, Piemonti L, Marchetti P, Lammert E
2012 Feb
Mechanoinduction of lymph vessel expansion.
Planas-Paz L, Strilić B, Goedecke A, Breier G, Fässler R, Lammert E
2011 Aug
CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo.
Bos FL, Caunt M, Peterson-Maduro J, Planas-Paz L, Kowalski J, Karpanen T, van Impel A, Tong R, Ernst JA, Korving J, van Es JH, Lammert E, Duckers HJ, Schulte-Merker S
2010 Jan
Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function.
Sordi V, Melzi R, Mercalli A, Formicola R, Doglioni C, Tiboni F, Ferrari G, Nano R, Chwalek K, Lammert E, Bonifacio E, Borg D, Piemonti L
2010 Nov
Electrostatic cell-surface repulsion initiates lumen formation in developing blood vessels.
Strilić B, Eglinger J, Krieg M, Zeeb M, Axnick J, Babál P, Müller DJ, Lammert E
2010 Oct
Resolving cell-cell junctions: lumen formation in blood vessels.
Zeeb M, Strilic B, Lammert E
2009 Nov
Quantitative proteomic analysis of single pancreatic islets.
Waanders LF, Chwalek K, Monetti M, Kumar C, Lammert E, Mann M
2009 Oct
The molecular basis of vascular lumen formation in the developing mouse aorta.
Strilić B, Kucera T, Eglinger J, Hughes MR, McNagny KM, Tsukita S, Dejana E, Ferrara N, Lammert E
2009 Oct
The pancreatic beta-cell in the islet and organ community.
Eberhard D, Lammert E
2008 Nov
Developmental biology. Brain Wnts for blood vessels.
Lammert E
2008 Sep
Reduced insulin secretion and content in VEGF-a deficient mouse pancreatic islets.
Jabs N, Franklin I, Brenner MB, Gromada J, Ferrara N, Wollheim CB, Lammert E
2007 Apr
EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets.
Konstantinova I, Nikolova G, Ohara-Imaizumi M, Meda P, Kucera T, Zarbalis K, Wurst W, Nagamatsu S, Lammert E
2007 Jan
The vascular niche and its basement membrane.
Nikolova G, Strilic B, Lammert E
2006 Mar
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.
Nikolova G, Jabs N, Konstantinova I, Domogatskaya A, Tryggvason K, Sorokin L, Fässler R, Gu G, Gerber HP, Ferrara N, Melton DA, Lammert E

Cooperations

Selektierte externe Kooperationspartner (alphabetisch)

  • Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach: Dr. P. Eickelmann, Dr. S.G. Kauschke, Dr. D. Schumann
  • Cisanello Krankenhaus, Pisa: Prof. Dr. P. Marchetti, Dr. M. Bugliani
  • Clinic for General Pediatrics, Düsseldorf: Dr. D. Herebian, Dr. J. Marquard, Prof. Dr. E. Mayatepek, PD Dr. T. Meissner
  • Harvard Medical School, Boston: Prof. Dr. N. Gray, Dr. Q. Liu, Dr. J. Wang
  • Hubrecht Institute, Utrecht: Prof. Dr. S. Schulte-Merker, F.L. Bos
  • Charles University, Prague: Prof. Dr. T. Kucera
  • Max Planck Institute for Biochemistry, Munich: Prof. Dr. R. Fässler, Prof. Dr. M. Mann
  • Osaka University, Osaka: Prof. Dr. S. Tsukita
  • Profil Institute for Clinical Research, Neuss: Dr. T. Heise, Prof. Dr. F. Schliess, Dr. A. Stirban
  • San Raffaele Scientific Institute, Milano: Dr. L. Piemonti
  • University Bremen: Prof. Dr. K. Maedler
  • University of British Columbia, Vancouver: Prof. Dr. K.M. McNagny, Dr. M.R. Hughes
  • University of California, San Diego: Prof. Dr. Napoleone Ferrara
  • University of Technology, Dresden: Prof. Dr. S. Bornstein, Prof. Dr. G. Breier, Dr. S. Speier



Support Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen Bundesministerium für Gesundheit

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